Bioinspired tough gel sheath for robust and versatile surface functionalization

Zhenwei Ma; Zhen Yang; Qiman Gao; Guangyu Bao; Amin Valiei; Fan Yang; Ran Huo; Chen Wang; Guolong Song; Dongling Ma; Zu Hua Gao; Jianyu Li

doi:10.1126/SCIADV.ABC3012

Bioinspired tough gel sheath for robust and versatile surface functionalization

Zhenwei Ma, Zhen Yang, Qiman Gao, Guangyu Bao, Amin Valiei, Fan Yang, Ran Huo, Chen Wang, Guolong Song, Dongling Ma, Zu Hua Gao, Jianyu Li

TMD and Orofacial Pain

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Sutures pervade surgeries, but their performance is limited by the mechanical mismatch with tissues and the lack of advanced functionality. Existing modification strategies result in either deterioration of suture's bulk properties or a weak coating susceptible to rupture or delamination. Inspired by tendon endotenon sheath, we report a versatile strategy to functionalize fiber-based devices such as sutures. This strategy seamlessly unites surgical sutures, tough gel sheath, and various functional materials. Robust modification is demonstrated with strong interfacial adhesion (>2000 J m-2). The surface stiffness, friction, and drag of the suture when interfacing with tissues can be markedly reduced, without compromising the tensile strength. Versatile functionalization of the suture for infection prevention, wound monitoring, drug delivery, and near-infrared imaging is then presented. This platform technology is applicable to other fiber-based devices and foreseen to affect broad technological areas ranging from wound management to smart textiles.

Original language	English (US)
Article number	eabc3012
Journal	Science Advances
Volume	7
Issue number	15
DOIs	https://doi.org/10.1126/SCIADV.ABC3012 https://doi.org/10.1126/SCIADV.ABC3012
State	Published - Apr 7 2021

Bibliographical note

Funding Information:
This work was supported by Natural Sciences and Engineering Research Council of Canada (NSERC, grant RGPIN-2018-04146), Canada Foundation for Innovation (grant 37719) and Fonds de Recherche du Qu?bec-Nature et technologies (FRQNT; grant NC-270740, PR-281851). Z.M. acknowledged the financial support from FRQNT Doctoral Research Scholarship and McGill Engineering Doctoral Award. D.M. was grateful for the financial support from NSERC and FRQNT.

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Copyright © 2021 The Authors, some rights reserved.

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abstract = "Sutures pervade surgeries, but their performance is limited by the mechanical mismatch with tissues and the lack of advanced functionality. Existing modification strategies result in either deterioration of suture's bulk properties or a weak coating susceptible to rupture or delamination. Inspired by tendon endotenon sheath, we report a versatile strategy to functionalize fiber-based devices such as sutures. This strategy seamlessly unites surgical sutures, tough gel sheath, and various functional materials. Robust modification is demonstrated with strong interfacial adhesion (>2000 J m-2). The surface stiffness, friction, and drag of the suture when interfacing with tissues can be markedly reduced, without compromising the tensile strength. Versatile functionalization of the suture for infection prevention, wound monitoring, drug delivery, and near-infrared imaging is then presented. This platform technology is applicable to other fiber-based devices and foreseen to affect broad technological areas ranging from wound management to smart textiles.",

author = "Zhenwei Ma and Zhen Yang and Qiman Gao and Guangyu Bao and Amin Valiei and Fan Yang and Ran Huo and Chen Wang and Guolong Song and Dongling Ma and Gao, {Zu Hua} and Jianyu Li",

note = "Funding Information: This work was supported by Natural Sciences and Engineering Research Council of Canada (NSERC, grant RGPIN-2018-04146), Canada Foundation for Innovation (grant 37719) and Fonds de Recherche du Qu?bec-Nature et technologies (FRQNT; grant NC-270740, PR-281851). Z.M. acknowledged the financial support from FRQNT Doctoral Research Scholarship and McGill Engineering Doctoral Award. D.M. was grateful for the financial support from NSERC and FRQNT. Publisher Copyright: Copyright {\textcopyright} 2021 The Authors, some rights reserved.",

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AU - Ma, Zhenwei

AU - Yang, Zhen

AU - Gao, Qiman

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AU - Yang, Fan

AU - Huo, Ran

AU - Wang, Chen

AU - Song, Guolong

AU - Ma, Dongling

AU - Gao, Zu Hua

AU - Li, Jianyu

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PY - 2021/4/7

Y1 - 2021/4/7

N2 - Sutures pervade surgeries, but their performance is limited by the mechanical mismatch with tissues and the lack of advanced functionality. Existing modification strategies result in either deterioration of suture's bulk properties or a weak coating susceptible to rupture or delamination. Inspired by tendon endotenon sheath, we report a versatile strategy to functionalize fiber-based devices such as sutures. This strategy seamlessly unites surgical sutures, tough gel sheath, and various functional materials. Robust modification is demonstrated with strong interfacial adhesion (>2000 J m-2). The surface stiffness, friction, and drag of the suture when interfacing with tissues can be markedly reduced, without compromising the tensile strength. Versatile functionalization of the suture for infection prevention, wound monitoring, drug delivery, and near-infrared imaging is then presented. This platform technology is applicable to other fiber-based devices and foreseen to affect broad technological areas ranging from wound management to smart textiles.

AB - Sutures pervade surgeries, but their performance is limited by the mechanical mismatch with tissues and the lack of advanced functionality. Existing modification strategies result in either deterioration of suture's bulk properties or a weak coating susceptible to rupture or delamination. Inspired by tendon endotenon sheath, we report a versatile strategy to functionalize fiber-based devices such as sutures. This strategy seamlessly unites surgical sutures, tough gel sheath, and various functional materials. Robust modification is demonstrated with strong interfacial adhesion (>2000 J m-2). The surface stiffness, friction, and drag of the suture when interfacing with tissues can be markedly reduced, without compromising the tensile strength. Versatile functionalization of the suture for infection prevention, wound monitoring, drug delivery, and near-infrared imaging is then presented. This platform technology is applicable to other fiber-based devices and foreseen to affect broad technological areas ranging from wound management to smart textiles.

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Bioinspired tough gel sheath for robust and versatile surface functionalization

Abstract

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