Bioinspired Mineralization with Hydroxyapatite and Hierarchical Naturally Aligned Nanofibrillar Cellulose

Yipin Qi, Zheng Cheng, Zhou Ye, Hongli Zhu, Conrado Aparicio

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

We used cellulose and a nonclassical mineralization process to fabricate a bioinspired nanohybrid material that exhibited structural features and properties similar to those of human hard tissues. We made a hydrogel with highly compacted and aligned cellulose nanofibers. We thoroughly mineralized the cellulose hydrogel with hydroxyapatite nanocrystals, using poly(acrylic acid) as a soluble template for precursor minerals, which infiltrated the nanocompartments of the aligned cellulose nanofiber network. The ultrastructure and mechanical properties of the mineralized gels were strikingly similar to those of bone and dentin, which supports further use of cellulose-based fibrillary materials as affordable, biocompatible scaffolds for repair and regeneration of hard tissues. The versatility of the bioinspired mineralization processes used here can broaden the applications of these cellulosic nanohybrids.

Original languageEnglish (US)
Pages (from-to)27598-27604
Number of pages7
JournalACS Applied Materials and Interfaces
Volume11
Issue number31
DOIs
StatePublished - Aug 7 2019

Bibliographical note

Funding Information:
H.Z. would like to thank the financial support from the Northeastern University. Parts of this work were carried out in the University of Minnesota I.T. Characterization Facility, which receives partial support from NSF through the MRSEC program. The authors thank David De Jong for editing the language of this paper.

Publisher Copyright:
© 2019 American Chemical Society.

Keywords

  • biomimetic
  • biomineralization
  • dentin
  • hydroxyapatite
  • nanocellulose

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