Bioinspired Intrinsic Versatile Hydrogel Fabricated by Amyloidal Toxin Simulant-Based Nanofibrous Assemblies for Accelerated Diabetic Wound Healing

Qize Xuan, Feng Jiang, Hao Dong, Wenxue Zhang, Feiyang Zhang, Tonghao Ma, Jiafeng Zhuang, Jinlong Yu, Yibing Wang, Hao Shen, Chao Chen, Ping Wang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Persistent microbial infection and decreased neovascularization are common issues associated with diabetic wound treatment. Hydrogel dressings that offer intrinsic antibacterial and angiogenesis-inducing may substantially avoid the use of antibiotics or angiogenic agents. Herein, a versatile hydrogel is fabricated using an amyloid-derived toxin simulant (Fmoc-LFKFFK-NH2, FLN) as building blocks, inspired by the defense strategy of Staphylococcus aureus (S. aureus). The simulant assemblies of the hydrogel function as both matrix components and functional elements for diabetic wound treatment. The hydrogel undergoes quick assembly from random monomers to nanofibrils with abundant b-sheet driven by multiple non-covalent interactions. The developed hydrogel demonstrates excellent biocompatibility and accelerates angiogenesis via hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor A (VEGFA) signaling as a consequence of its amyloidal structure. The simulant-based nanofibrils endow the hydrogel with broad-spectrum antibacterial activity dominated by a membrane-disruption mechanism. In addition, the hydrogel exhibits excellent performance compared with the commercial hydrogel Prontosan in accelerating wound healing of diabetic mice infected with methicillin-resistant S. aureus (MRSA). This study highlights the fabrication of a single component and versatile hydrogel platform, thereby avoiding the drug-related side effects and complicated preparations and demonstrating its profound potential as a clinical dressing for the management of microbe-infected diabetic wounds.

Original languageEnglish (US)
Article number2106705
JournalAdvanced Functional Materials
Volume31
Issue number49
DOIs
StatePublished - Dec 2 2021

Bibliographical note

Funding Information:
Q.X. and F.J. contributed equally to this work. This work was sponsored by the National Natural Science Foundation of China (Grant Nos. 81772364, 21908059, 41907318, and 21636003), Medical Guidance Scientific Research Support Project of Shanghai Science and Technology Commission (Grant No. 19411962600), the China Postdoctoral Science Foundation (Grant No. 2019M651419), Shanghai Sailing Program (Grant No. 19YF1410900), the Fundamental Research Funds for the Central Universities (Grant No. 22221818014), the Shanghai Post‐doctoral Excellence Program (Grant No. 2018011), and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering. The authors also thank the Research Centre of Analysis and Test of East China University of Science and Technology for the help with the TEM characterization of hydrogel.

Funding Information:
Q.X. and F.J. contributed equally to this work. This work was sponsored by the National Natural Science Foundation of China (Grant Nos. 81772364, 21908059, 41907318, and 21636003), Medical Guidance Scientific Research Support Project of Shanghai Science and Technology Commission (Grant No. 19411962600), the China Postdoctoral Science Foundation (Grant No. 2019M651419), Shanghai Sailing Program (Grant No. 19YF1410900), the Fundamental Research Funds for the Central Universities (Grant No. 22221818014), the Shanghai Post-doctoral Excellence Program (Grant No. 2018011), and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering. The authors also thank the Research Centre of Analysis and Test of East China University of Science and Technology for the help with the TEM characterization of hydrogel.

Publisher Copyright:
© 2021 Wiley-VCH GmbH

Keywords

  • amyloid
  • chronic wounds
  • intrinsic versatile hydrogel
  • peptide assembly
  • wound dressings

Fingerprint

Dive into the research topics of 'Bioinspired Intrinsic Versatile Hydrogel Fabricated by Amyloidal Toxin Simulant-Based Nanofibrous Assemblies for Accelerated Diabetic Wound Healing'. Together they form a unique fingerprint.

Cite this