Bioinformatics analysis of experimentally determined protein complexes in the yeast Saccharomyces cerevisiae

Zoltán Dezso, Zoltán N. Oltvai, Albert László Barabási

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Many important cellular functions are implemented by protein complexes that act as sophisticated molecular machines of varying size and temporal stability. Here we demonstrate quantitatively that protein complexes in the yeast Saccharomyces cerevisiae are comprised of a core in which subunits are highly coexpressed, display the same deletion phenotype (essential or nonessential), and share identical functional classification and cellular localization. This core is surrounded by a functionally mixed group of proteins, which likely represent short-lived or spurious attachments. The results allow us to define the deletion phenotype and cellular task of most known complexes, and to identify with high confidence the biochemical role of hundreds of proteins with yet unassigned functionality.

Original languageEnglish (US)
Pages (from-to)2450-2454
Number of pages5
JournalGenome research
Volume13
Issue number11
DOIs
StatePublished - Nov 2003

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