Biogenesis of extracellular vesicles (EV)

Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

Johnny C. Akers, David Gonda, Ryan Kim, Bob S. Carter, Clark C Chen

Research output: Contribution to journalReview article

341 Citations (Scopus)

Abstract

Recent studies suggest both normal and cancerous cells secrete vesicles into the extracellular space. These extracellular vesicles (EVs) contain materials that mirror the genetic and proteomic content of the secreting cell. The identification of cancer-specific material in EVs isolated from the biofluids (e.g., serum, cerebrospinal fluid, urine) of cancer patients suggests EVs as an attractive platform for biomarker development. It is important to recognize that the EVs derived from clinical samples are likely highly heterogeneous in make-up and arose from diverse sets of biologic processes. This article aims to review the biologic processes that give rise to various types of EVs, including exosomes, microvesicles, retrovirus like particles, and apoptotic bodies. Clinical pertinence of these EVs to neuro-oncology will also be discussed.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalJournal of Neuro-Oncology
Volume113
Issue number1
DOIs
StatePublished - Mar 4 2013
Externally publishedYes

Fingerprint

Exosomes
Retroviridae
Extracellular Space
Extracellular Vesicles
Proteomics
Cerebrospinal Fluid
Neoplasms
Biomarkers
Urine
Serum

Keywords

  • Biomarkers
  • Cancer
  • Intracellular trafficking
  • Membrane budding
  • Multi-vesicular bodies (MVB)
  • Tetraspanin
  • Tumor microenvironment

Cite this

Biogenesis of extracellular vesicles (EV) : Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. / Akers, Johnny C.; Gonda, David; Kim, Ryan; Carter, Bob S.; Chen, Clark C.

In: Journal of Neuro-Oncology, Vol. 113, No. 1, 04.03.2013, p. 1-11.

Research output: Contribution to journalReview article

Akers, Johnny C. ; Gonda, David ; Kim, Ryan ; Carter, Bob S. ; Chen, Clark C. / Biogenesis of extracellular vesicles (EV) : Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. In: Journal of Neuro-Oncology. 2013 ; Vol. 113, No. 1. pp. 1-11.
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