TY - JOUR
T1 - Biogenesis of extracellular vesicles (EV)
T2 - Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies
AU - Akers, Johnny C.
AU - Gonda, David
AU - Kim, Ryan
AU - Carter, Bob S.
AU - Chen, Clark C.
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2013/5
Y1 - 2013/5
N2 - Recent studies suggest both normal and cancerous cells secrete vesicles into the extracellular space. These extracellular vesicles (EVs) contain materials that mirror the genetic and proteomic content of the secreting cell. The identification of cancer-specific material in EVs isolated from the biofluids (e.g., serum, cerebrospinal fluid, urine) of cancer patients suggests EVs as an attractive platform for biomarker development. It is important to recognize that the EVs derived from clinical samples are likely highly heterogeneous in make-up and arose from diverse sets of biologic processes. This article aims to review the biologic processes that give rise to various types of EVs, including exosomes, microvesicles, retrovirus like particles, and apoptotic bodies. Clinical pertinence of these EVs to neuro-oncology will also be discussed.
AB - Recent studies suggest both normal and cancerous cells secrete vesicles into the extracellular space. These extracellular vesicles (EVs) contain materials that mirror the genetic and proteomic content of the secreting cell. The identification of cancer-specific material in EVs isolated from the biofluids (e.g., serum, cerebrospinal fluid, urine) of cancer patients suggests EVs as an attractive platform for biomarker development. It is important to recognize that the EVs derived from clinical samples are likely highly heterogeneous in make-up and arose from diverse sets of biologic processes. This article aims to review the biologic processes that give rise to various types of EVs, including exosomes, microvesicles, retrovirus like particles, and apoptotic bodies. Clinical pertinence of these EVs to neuro-oncology will also be discussed.
KW - Biomarkers
KW - Cancer
KW - Intracellular trafficking
KW - Membrane budding
KW - Multi-vesicular bodies (MVB)
KW - Tetraspanin
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=84874355076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874355076&partnerID=8YFLogxK
U2 - 10.1007/s11060-013-1084-8
DO - 10.1007/s11060-013-1084-8
M3 - Review article
C2 - 23456661
AN - SCOPUS:84874355076
SN - 0167-594X
VL - 113
SP - 1
EP - 11
JO - Journal of neuro-oncology
JF - Journal of neuro-oncology
IS - 1
ER -
