Bioengineered Hybrid Rep 2/6 Gene Improves Encapsulation of a Single-Stranded Expression Cassette into AAV6 Vectors

Keyphrases

• Bioengineering 100%
• Adeno-associated Viral 100%
• Expression Cassette 100%
• AAV6 100%
• Adeno-associated Viral Vector 40%
• Rep Gene 40%
• Amino Acids 20%
• Gene Therapy 20%
• Recombinant 20%
• Immunogenicity 20%
• Manufacturing Process 20%
• Clinical Grade 20%
• Ligand-binding Domain 20%
• Hybrid Genes 20%
• Serotype 2 20%
• Recombinant Viral Vectors 20%
• In Vivo Activity 20%
• Gene Therapy Trials 20%
• Naturally Isolated 20%
• Capsid Modification 20%
• Vector Production 20%
• Serotype 6 20%
• Empty Capsids 20%
• ITR2 20%
• Nonstructural Components 20%
• Improved Packaging 20%
• Viral Capsid 20%
• Vector Genomes 20%

Biochemistry, Genetics and Molecular Biology

• Capsid 100%
• Expression Cassette 100%
• Adeno Associated Virus Vector 100%
• Gene Therapy 66%
• Serotype 66%
• Amino Acids 33%
• Wild Type 33%
• Recombinant 33%
• Binding Domain 33%
• Scale up 33%
• Hybrid Gene 33%
• Immunogenicity 33%