"Bioelectronic super-taster" device based on taste receptor-carbon nanotube hybrid structures

Tae Hyun Kim, Hyun Seok Song, Hye Jun Jin, Sang Hun Lee, Seon Namgung, Un Kyung Kim, Tai Hyun Park, Seunghun Hong

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

We have developed a method to monitor the activities of human taste receptor protein in lipid membrane using carbon nanotube transistors, enabling a "bioelectronic super-taster (BST)", a taste sensor with human-tongue-like selectivity. In this work, human bitter taste receptor protein expressed in E. coli was immobilized on a single-walled carbon nanotube field effect transistor (swCNT-FET) with the lipid membrane. Then, the protein binding activity was monitored using the underlying swCNT-FET, leading to the operation as a BST device. The fabricated BST device could detect bitter tastants at 100 fM concentrations and distinguish between bitter and non-bitter tastants with similar chemical structures just like a human tongue. Furthermore, this strategy was utilized to differentiate the responses of taster or non-taster types of the bitter taste receptor proteins.

Original languageEnglish (US)
Pages (from-to)2262-2267
Number of pages6
JournalLab on a chip
Volume11
Issue number13
DOIs
StatePublished - Jul 7 2011

Fingerprint Dive into the research topics of '"Bioelectronic super-taster" device based on taste receptor-carbon nanotube hybrid structures'. Together they form a unique fingerprint.

  • Cite this

    Kim, T. H., Song, H. S., Jin, H. J., Lee, S. H., Namgung, S., Kim, U. K., Park, T. H., & Hong, S. (2011). "Bioelectronic super-taster" device based on taste receptor-carbon nanotube hybrid structures. Lab on a chip, 11(13), 2262-2267. https://doi.org/10.1039/c0lc00648c