Biodemographic trajectories of longevity

James W. Vaupel, James R. Carey, Kaare Christensen, Thomas E. Johnson, Anatoli I. Yashin, Niels V. Holm, Ivan A. Iachine, Väinö Kannisto, Aziz A. Khazaeli, Pablo Liedo, Valter D. Longo, Yi Zeng, Kenneth G. Manton, James W. Curtsinger

Research output: Contribution to journalReview article

689 Scopus citations

Abstract

Old-age survival has increased substantially since 1950. Death rates decelerate with age for insects, worms, and yeast, as well as humans. This evidence of extended postreproductive survival is puzzling. Three biodemographic insights - concerning the correlation of death rates across age, individual differences in survival chances, and induced alterations in age patterns of fertility and mortality - offer clues and suggest research on the failure of complicated systems, on new demographic equation for evolutionary theory, and on fertility-longevity interactions. Nongenetic changes account for increases in human life-spans to date. Explications of these causes and the genetic license for extended survival, as well as discovery of genes and other survival attributes affecting longevity, will lead to even longer lives.

Original languageEnglish (US)
Pages (from-to)855-860
Number of pages6
JournalScience
Volume280
Issue number5365
DOIs
StatePublished - May 8 1998

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    Vaupel, J. W., Carey, J. R., Christensen, K., Johnson, T. E., Yashin, A. I., Holm, N. V., Iachine, I. A., Kannisto, V., Khazaeli, A. A., Liedo, P., Longo, V. D., Zeng, Y., Manton, K. G., & Curtsinger, J. W. (1998). Biodemographic trajectories of longevity. Science, 280(5365), 855-860. https://doi.org/10.1126/science.280.5365.855