Biodegradable starch particles for controlled release applications: Swelling and leaching mechanisms

Juliana Dias Maia, Marcio Schmiele, Job Ubbink, Ana Silvia Prata

Research output: Contribution to journalArticlepeer-review

Abstract

Starch-extruded particles have only found infrequent use as delivery systems for active ingredients. We have previously shown that these particles are attractive for releasing hydrophobic compounds in water media. Here, we cover a range of amylose–amylopectin ratios and evaluate the presence of the thyme essential oil (TEO) as active compound to understand the dominant release mechanism in relation to the physicochemical properties of the starch matrices. Starch blends with high amylopectin content (1.8 and 15% amylose) could not be shaped into regular particles. For amylose contents higher than 28%, the equilibrium degree of swelling in water decreased with increasing amylose contents, from nearly 300% for an amylose content of 28–90% at an amylose content of 70%. For both lowest amylose contents, 1.8 and 15%, leaching of solids and disintegration of the particles resulted in a low apparent degree of swelling. The presence of TEO reduces the degree of swelling of the gelatinized starch matrix. This is explained by the formation of thymol–amylose complexes, which is confirmed by Fourier transform infrared spectroscopy analysis and X-ray diffraction.

Original languageEnglish (US)
Article number49007
JournalJournal of Applied Polymer Science
Volume137
Issue number34
DOIs
StatePublished - Sep 10 2020

Bibliographical note

Funding Information:
CAPES, Grant/Award Number: 001; FAPESP, Grant/Award Number: 16/09824‐4; UNICAMP Funding information

Funding Information:
The research reported in this article is part of a project on the development of biodegradable controlled release system for natural larvicides (Principal Investigator: A.S.P., co‐Principal Investigator: J.U.). The authors wish to thank UNICAMP (University of Campinas, Brazil), FAPESP (São Paulo Research Foundation, Brazil; Process #16/09824‐4), and CAPES (Coordination for the Improvement of Higher Education Personnel, Brazil; process #001) for financial support and for the scholarship for J.D.M. The Laboratory of cereals, roots, and tubers of UNICAMP is thanked for the support in the execution of the extrusion process and the Laboratory of Food Innovation of UNICAMP is thanked for the general support.

Keywords

  • biodegradable
  • drug delivery systems
  • polysaccharides
  • swelling

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