Biocompatible patterning of proteins on wettability gradient surface by thermo-transfer printing

Sungho Kim; Yong Sang Ryu; Jeng Hun Suh; Chang Min Keum; Youngjoo Sohn; Sin Doo Lee

doi:10.1166/jnn.2014.8828

Biocompatible patterning of proteins on wettability gradient surface by thermo-transfer printing

Sungho Kim, Yong Sang Ryu, Jeng Hun Suh, Chang Min Keum, Youngjoo Sohn, Sin Doo Lee

Electrical and Computer Engineering

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

We develop a simple and biocompatible method of patterning proteins on a wettability gradient surface by thermo-transfer printing. The wettability gradient is produced on a poly(dimethylsiloxane) (PDMS)-modified glass substrate through the temperature gradient during thermo-transfer printing. The water contact angle on the PDMS-modified surface is found to gradually increase along the direction of the temperature gradient from a low to a high temperature region. Based on the wettability gradient, the gradual change in the adsorption and immobilization of proteins (cholera toxin B subunit) is achieved in a microfluidic cell with the PDMS-modified surface.

Original language	English (US)
Pages (from-to)	6069-6071
Number of pages	3
Journal	Journal of Nanoscience and Nanotechnology
Volume	14
Issue number	8
DOIs	https://doi.org/10.1166/jnn.2014.8828
State	Published - Aug 2014

Keywords

PDMS transfer
Protein array
Protein binding
Wettability gradient

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title = "Biocompatible patterning of proteins on wettability gradient surface by thermo-transfer printing",

abstract = "We develop a simple and biocompatible method of patterning proteins on a wettability gradient surface by thermo-transfer printing. The wettability gradient is produced on a poly(dimethylsiloxane) (PDMS)-modified glass substrate through the temperature gradient during thermo-transfer printing. The water contact angle on the PDMS-modified surface is found to gradually increase along the direction of the temperature gradient from a low to a high temperature region. Based on the wettability gradient, the gradual change in the adsorption and immobilization of proteins (cholera toxin B subunit) is achieved in a microfluidic cell with the PDMS-modified surface.",

keywords = "PDMS transfer, Protein array, Protein binding, Wettability gradient",

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AU - Kim, Sungho

AU - Ryu, Yong Sang

AU - Suh, Jeng Hun

AU - Keum, Chang Min

AU - Sohn, Youngjoo

AU - Lee, Sin Doo

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AB - We develop a simple and biocompatible method of patterning proteins on a wettability gradient surface by thermo-transfer printing. The wettability gradient is produced on a poly(dimethylsiloxane) (PDMS)-modified glass substrate through the temperature gradient during thermo-transfer printing. The water contact angle on the PDMS-modified surface is found to gradually increase along the direction of the temperature gradient from a low to a high temperature region. Based on the wettability gradient, the gradual change in the adsorption and immobilization of proteins (cholera toxin B subunit) is achieved in a microfluidic cell with the PDMS-modified surface.

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KW - Protein array

KW - Protein binding

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