Biocompatible patterning of proteins on wettability gradient surface by thermo-transfer printing

Sungho Kim, Yong Sang Ryu, Jeng Hun Suh, Chang Min Keum, Youngjoo Sohn, Sin Doo Lee

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We develop a simple and biocompatible method of patterning proteins on a wettability gradient surface by thermo-transfer printing. The wettability gradient is produced on a poly(dimethylsiloxane) (PDMS)-modified glass substrate through the temperature gradient during thermo-transfer printing. The water contact angle on the PDMS-modified surface is found to gradually increase along the direction of the temperature gradient from a low to a high temperature region. Based on the wettability gradient, the gradual change in the adsorption and immobilization of proteins (cholera toxin B subunit) is achieved in a microfluidic cell with the PDMS-modified surface.

Original languageEnglish (US)
Pages (from-to)6069-6071
Number of pages3
JournalJournal of Nanoscience and Nanotechnology
Volume14
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • PDMS transfer
  • Protein array
  • Protein binding
  • Wettability gradient

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