Biocompatible high-moment FeCo-Au magnetic nanoparticles for magnetic hyperthermia treatment optimization

Timothy L. Kline, Yun Hao Xu, Ying Jing, Jianping Wang

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

A great deal of attention has been paid to the use of magnetite nanoparticles as heating elements in the research of magnetic fluid hyperthermia. However, these particles have a relatively low magnetization and as a result, have low heating efficiency as well as difficulties in detection applications. To maximize heating efficiency we propose and show the use of high-moment Fe(Co)-Au core-shell nanoparticles. Using a physical vapor nanoparticle-deposition technique the high-moment nanoparticles were synthesized. The water-soluble particles were placed in an AC magnetic field of variable magnetic field frequencies. The temperature rise was measured and compared to theory.

Original languageEnglish (US)
Pages (from-to)1525-1528
Number of pages4
JournalJournal of Magnetism and Magnetic Materials
Volume321
Issue number10
DOIs
StatePublished - May 2009

Bibliographical note

Funding Information:
The authors would like to thank the National Science Foundation for part of the financial support for this work under grant NSF BME 075345 and the Institute of Engineering in Medicine through the Medical Device Center at the University of Minnesota. Also, for help with the Dynamic Light Scattering measurements, we thank Pengyun Zeng in the Pharmacy Department at the University of Minnesota. We also thank the help of Prof. Andy Taton and Dr. Ying Zhang of Chemistry Department, University of Minnesota.

Keywords

  • Au shell
  • Cancer treatment
  • Core-shell
  • High-moment
  • Hyperthermia
  • Magnetic fluid
  • Nanoparticles
  • Physical vapor deposition
  • Specific absorption rate
  • Tumor cell

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