Biocompatibility of chemical-vapour-deposited diamond

L. Tang; C. Tsai; W. W. Gerberich; L. Kruckeberg; D. R. Kania

doi:10.1016/0142-9612(95)98822-V

Biocompatibility of chemical-vapour-deposited diamond

L. Tang, C. Tsai, W. W. Gerberich, L. Kruckeberg, D. R. Kania

Chemical Engineering and Materials Science

Research output: Contribution to journal › Article › peer-review

282 Scopus citations

Abstract

The biocompatibility of chemical-vapour-deposited (CVD) diamond surfaces has been assessed. Our results indicate that CVD diamond is as biocompatible as titanium (Ti) and 316 stainless steel (SS). First, the amount of adsorbed and 'denatured' fibrinogen on CVD diamond was very close to that of Ti and SS. Second, both in vitro and in vivo there appears to be less cellular adhesion and activation on the surface of CVD diamond surfaces compared to Ti and SS. This evident biocompatibility, coupled with the corrosion resistance and notable mechanical integrity of CVD diamond, suggests that diamond-coated surfaces may be highly desirable in a number of biomedical applications.

Original language	English (US)
Pages (from-to)	483-488
Number of pages	6
Journal	Biomaterials
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/0142-9612(95)98822-V
State	Published - 1995

Bibliographical note

Funding Information:
The authors would like to acknowledge S.R. Bergman for technical assistance. One of us (W.W.G.) would like to acknowledge the support of the Center for Interfacial Engineering at the University of Minnesota under grant number NSF/CDR-8721551.

Keywords

Chemical-vapour-deposited diamond
biocompatibility
fibrinogen
implants
neutrophils

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10.1016/0142-9612(95)98822-V

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title = "Biocompatibility of chemical-vapour-deposited diamond",

abstract = "The biocompatibility of chemical-vapour-deposited (CVD) diamond surfaces has been assessed. Our results indicate that CVD diamond is as biocompatible as titanium (Ti) and 316 stainless steel (SS). First, the amount of adsorbed and 'denatured' fibrinogen on CVD diamond was very close to that of Ti and SS. Second, both in vitro and in vivo there appears to be less cellular adhesion and activation on the surface of CVD diamond surfaces compared to Ti and SS. This evident biocompatibility, coupled with the corrosion resistance and notable mechanical integrity of CVD diamond, suggests that diamond-coated surfaces may be highly desirable in a number of biomedical applications.",

keywords = "Chemical-vapour-deposited diamond, biocompatibility, fibrinogen, implants, neutrophils",

author = "L. Tang and C. Tsai and Gerberich, {W. W.} and L. Kruckeberg and Kania, {D. R.}",

note = "Funding Information: The authors would like to acknowledge S.R. Bergman for technical assistance. One of us (W.W.G.) would like to acknowledge the support of the Center for Interfacial Engineering at the University of Minnesota under grant number NSF/CDR-8721551.",

year = "1995",

doi = "10.1016/0142-9612(95)98822-V",

language = "English (US)",

volume = "16",

pages = "483--488",

journal = "Biomaterials",

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T1 - Biocompatibility of chemical-vapour-deposited diamond

AU - Tang, L.

AU - Tsai, C.

AU - Gerberich, W. W.

AU - Kruckeberg, L.

AU - Kania, D. R.

N1 - Funding Information: The authors would like to acknowledge S.R. Bergman for technical assistance. One of us (W.W.G.) would like to acknowledge the support of the Center for Interfacial Engineering at the University of Minnesota under grant number NSF/CDR-8721551.

PY - 1995

Y1 - 1995

N2 - The biocompatibility of chemical-vapour-deposited (CVD) diamond surfaces has been assessed. Our results indicate that CVD diamond is as biocompatible as titanium (Ti) and 316 stainless steel (SS). First, the amount of adsorbed and 'denatured' fibrinogen on CVD diamond was very close to that of Ti and SS. Second, both in vitro and in vivo there appears to be less cellular adhesion and activation on the surface of CVD diamond surfaces compared to Ti and SS. This evident biocompatibility, coupled with the corrosion resistance and notable mechanical integrity of CVD diamond, suggests that diamond-coated surfaces may be highly desirable in a number of biomedical applications.

AB - The biocompatibility of chemical-vapour-deposited (CVD) diamond surfaces has been assessed. Our results indicate that CVD diamond is as biocompatible as titanium (Ti) and 316 stainless steel (SS). First, the amount of adsorbed and 'denatured' fibrinogen on CVD diamond was very close to that of Ti and SS. Second, both in vitro and in vivo there appears to be less cellular adhesion and activation on the surface of CVD diamond surfaces compared to Ti and SS. This evident biocompatibility, coupled with the corrosion resistance and notable mechanical integrity of CVD diamond, suggests that diamond-coated surfaces may be highly desirable in a number of biomedical applications.

KW - Chemical-vapour-deposited diamond

KW - biocompatibility

KW - fibrinogen

KW - implants

KW - neutrophils

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U2 - 10.1016/0142-9612(95)98822-V

DO - 10.1016/0142-9612(95)98822-V

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AN - SCOPUS:0029278157

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VL - 16

SP - 483

EP - 488

JO - Biomaterials

JF - Biomaterials

IS - 6

ER -

Biocompatibility of chemical-vapour-deposited diamond

Abstract

Bibliographical note

Keywords

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