The biocompatibility of chemical-vapour-deposited (CVD) diamond surfaces has been assessed. Our results indicate that CVD diamond is as biocompatible as titanium (Ti) and 316 stainless steel (SS). First, the amount of adsorbed and 'denatured' fibrinogen on CVD diamond was very close to that of Ti and SS. Second, both in vitro and in vivo there appears to be less cellular adhesion and activation on the surface of CVD diamond surfaces compared to Ti and SS. This evident biocompatibility, coupled with the corrosion resistance and notable mechanical integrity of CVD diamond, suggests that diamond-coated surfaces may be highly desirable in a number of biomedical applications.
Bibliographical noteFunding Information:
The authors would like to acknowledge S.R. Bergman for technical assistance. One of us (W.W.G.) would like to acknowledge the support of the Center for Interfacial Engineering at the University of Minnesota under grant number NSF/CDR-8721551.
- Chemical-vapour-deposited diamond