Biochemical specificity in central pathways related to peripheral and intracerebral homeostatic functions

L. W. Swanson; B. K. Hartman

doi:10.1016/0304-3940(80)90100-7

Biochemical specificity in central pathways related to peripheral and intracerebral homeostatic functions

L. W. Swanson, B. K. Hartman

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Abstract

Immunohistochemical and horseradish peroxidase (HRP) studies suggest that oxytocin-stained fibers from the paraventricular nucleus of the hypothalamus (PVH) innervate the locus coeruleus (LC) and dorsal vagal complex (DVC) in the brainstem of the rat, and that adrenergic fibers from the LC and DVC in turn project to the PVH. It is hypothesized that these pathways are directly involved in the integration of neuroendocrine and autonomic responses in the periphery, as well as in the mediation of homeostatic-preserving responses within the CNS itself.

Original language	English (US)
Pages (from-to)	55-60
Number of pages	6
Journal	Neuroscience Letters
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(80)90100-7
State	Published - Jan 1980
Externally published	Yes

Bibliographical note

Funding Information:
We thank Drs. K. Dierickx and F. Vandesande for generous supplies of antisem ~oxytocin, ~H and neurophysi~ The work was supported in USPHS grant N813267, by a grant from the Sloan Foundation (to L.W. Swanson), and by USPHS grants NS12311, NS13672 and Research ScientistD evelopment Award ~ 70451 (to B.K. Hartman).

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title = "Biochemical specificity in central pathways related to peripheral and intracerebral homeostatic functions",

abstract = "Immunohistochemical and horseradish peroxidase (HRP) studies suggest that oxytocin-stained fibers from the paraventricular nucleus of the hypothalamus (PVH) innervate the locus coeruleus (LC) and dorsal vagal complex (DVC) in the brainstem of the rat, and that adrenergic fibers from the LC and DVC in turn project to the PVH. It is hypothesized that these pathways are directly involved in the integration of neuroendocrine and autonomic responses in the periphery, as well as in the mediation of homeostatic-preserving responses within the CNS itself.",

author = "Swanson, {L. W.} and Hartman, {B. K.}",

note = "Funding Information: We thank Drs. K. Dierickx and F. Vandesande for generous supplies of antisem ~oxytocin, ~H and neurophysi~ The work was supported in USPHS grant N813267, by a grant from the Sloan Foundation (to L.W. Swanson), and by USPHS grants NS12311, NS13672 and Research ScientistD evelopment Award ~ 70451 (to B.K. Hartman).",

year = "1980",

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doi = "10.1016/0304-3940(80)90100-7",

language = "English (US)",

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journal = "Neuroscience Letters",

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AU - Swanson, L. W.

AU - Hartman, B. K.

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PY - 1980/1

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N2 - Immunohistochemical and horseradish peroxidase (HRP) studies suggest that oxytocin-stained fibers from the paraventricular nucleus of the hypothalamus (PVH) innervate the locus coeruleus (LC) and dorsal vagal complex (DVC) in the brainstem of the rat, and that adrenergic fibers from the LC and DVC in turn project to the PVH. It is hypothesized that these pathways are directly involved in the integration of neuroendocrine and autonomic responses in the periphery, as well as in the mediation of homeostatic-preserving responses within the CNS itself.

AB - Immunohistochemical and horseradish peroxidase (HRP) studies suggest that oxytocin-stained fibers from the paraventricular nucleus of the hypothalamus (PVH) innervate the locus coeruleus (LC) and dorsal vagal complex (DVC) in the brainstem of the rat, and that adrenergic fibers from the LC and DVC in turn project to the PVH. It is hypothesized that these pathways are directly involved in the integration of neuroendocrine and autonomic responses in the periphery, as well as in the mediation of homeostatic-preserving responses within the CNS itself.

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Biochemical specificity in central pathways related to peripheral and intracerebral homeostatic functions

Abstract

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