Biochemical pathology of otitis media with effusion

S. K. Juhn, P. Sipila, T. T K Jung, J. Edlin

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The sequential cytologic and biochemical events of middle ear effusion (MEE) were studied in experimental models of serous otitis media (SOM) and purulent otitis media (POM) in chinchilla. In the SOM model, the initial appearance of neutrophils was followed by macrophages. In the POM model, neutrophils were the predominant cells in MEE and the number of neutrophils was about 100-fold higher than in the SOM model. The activity of lysozyme in MEE was higher in POM than in SOM and correlated with the number of neutrophils and mononuclear phagocytes. The results of the present study suggest that neutrophils and mononuclear phagocytes are one of the main sources for lysozyme levels in MEE during otitis media.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalActa Oto-Laryngologica
Issue numberSUPPL. 414
StatePublished - 1984

Bibliographical note

Funding Information:
This research was supported by NINCDS grant NS14538 and a grant from the Academy of Finland.

PubMed: MeSH publication types

  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.


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