TY - JOUR
T1 - Biochemical effects of the plant Lantana camara on guinea pig liver mitochondria
AU - Sharma, O. P.
AU - Makkar, H. P.S.
AU - Dawra, R. K.
PY - 1982
Y1 - 1982
N2 - Lantana camara caused, in guinea pigs, a decrease in hepatic mitochondrial protein content. The phospholipid to protein ratio did not change but there was a marked increase in the cholesterol to protein ratio and the cholesterol to phospholipid ratio. Enzyme activities of succinic dehydrogenase, glutamate dehydrogenase, cytochrome oxidase and Mg2+-ATPase increased, while the activity of NADH-ferricyanide reductase remained unaffected. Mitochondrial swelling, in the absence or presence of ascorbic acid, decreased in hepatic mitochondria from lantana-intoxicated guinea pigs.
AB - Lantana camara caused, in guinea pigs, a decrease in hepatic mitochondrial protein content. The phospholipid to protein ratio did not change but there was a marked increase in the cholesterol to protein ratio and the cholesterol to phospholipid ratio. Enzyme activities of succinic dehydrogenase, glutamate dehydrogenase, cytochrome oxidase and Mg2+-ATPase increased, while the activity of NADH-ferricyanide reductase remained unaffected. Mitochondrial swelling, in the absence or presence of ascorbic acid, decreased in hepatic mitochondria from lantana-intoxicated guinea pigs.
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U2 - 10.1016/0041-0101(82)90125-8
DO - 10.1016/0041-0101(82)90125-8
M3 - Article
C2 - 7135417
AN - SCOPUS:0020459870
SN - 0041-0101
VL - 20
SP - 783
EP - 786
JO - Toxicon
JF - Toxicon
IS - 4
ER -
