TY - JOUR
T1 - Biochemical changes in hepatic microsomes of Guinea-pig under lantana toxicity
AU - Sharma, O. P.
AU - Makkar, H. P.S.
AU - Dawra, R. K.
PY - 1982
Y1 - 1982
N2 - 1. Lantana intoxication of guinea-pig caused a decrease in hepatic microsomal protein content, the phospholipid: protein ratio, and the cholesterol: protein ratio. 2. Activities of aniline hydroxylase, aminopyrine N-demethylase, NADH-cytochrome c reductase, NADH-ferricyanide reductase, UDP-glucuronosyl transferase, cytochrome P-450 and glucose 6-phosphatase were decreased. 3. Activities of Mg2+-ATPase and Na+-K+-ATPase were increased. However, activities of 5-nucleotidase and NADPH-cytochrome c reductase were unaffected. 4. The liver endoplasmic reticulum is an important target organelle during lantana poisoning of guinea-pigs.
AB - 1. Lantana intoxication of guinea-pig caused a decrease in hepatic microsomal protein content, the phospholipid: protein ratio, and the cholesterol: protein ratio. 2. Activities of aniline hydroxylase, aminopyrine N-demethylase, NADH-cytochrome c reductase, NADH-ferricyanide reductase, UDP-glucuronosyl transferase, cytochrome P-450 and glucose 6-phosphatase were decreased. 3. Activities of Mg2+-ATPase and Na+-K+-ATPase were increased. However, activities of 5-nucleotidase and NADPH-cytochrome c reductase were unaffected. 4. The liver endoplasmic reticulum is an important target organelle during lantana poisoning of guinea-pigs.
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U2 - 10.3109/00498258209052465
DO - 10.3109/00498258209052465
M3 - Article
C2 - 7113263
AN - SCOPUS:0019995207
SN - 0049-8254
VL - 12
SP - 265
EP - 269
JO - Xenobiotica
JF - Xenobiotica
IS - 4
ER -
