Bioavailability and pulmonary first-pass removal of etretinate in rats

P. Thongnopnua, C. L. Zimmerman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The oral bioavailability of etretinate (ET) and its presystemic loss due to pulmonary extraction were studied in the rat. The oral bioavailability was found to be 15%. The percentage of a dose of ET escaping pulmonary extraction was estimated to be 49%. These data suggest substantial presystemic loss of ET, including significant extraction by the lungs.

Original languageEnglish (US)
Pages (from-to)269-272
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume61
Issue number2
StatePublished - 1988

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