Abstract
The oral bioavailability of etretinate (ET) and its presystemic loss due to pulmonary extraction were studied in the rat. The oral bioavailability was found to be 15%. The percentage of a dose of ET escaping pulmonary extraction was estimated to be 49%. These data suggest substantial presystemic loss of ET, including significant extraction by the lungs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 269-272 |
| Number of pages | 4 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 61 |
| Issue number | 2 |
| State | Published - 1988 |