Bioanalysis of eukaryotic organelles

Chad P. Satori, Michelle M. Henderson, Elyse A. Krautkramer, Vratislav Kostal, Mark D Distefano, Edgar Arriaga

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

The role that organelle analysis has played in understanding biology is studied. Organelle analysis enables a more specific description of the molecular, biochemical, and physiological processes associated with diseases, embryonic development, tissue differentiation, organism aging, disease treatments, and organism response to pathogens. Confocal microscopy has become a routine tool for investigating subcellular organization, organelle networks, and organelle dynamics in cellular and tissue samples. Most organelles have a dynamic, three-dimensional (3D) organization inside the cell, which is tightly connected to their physiological functions. Due to this, a single 2D image inherently limits the information acquired about the distribution of a particular property within the organelle. The combination of subcellular fractionation with 'omic' technologies has become a powerful resource to characterize and catalogue the various subcellular environments in a cell.

Original languageEnglish (US)
Pages (from-to)2733-2811
Number of pages79
JournalChemical Reviews
Volume113
Issue number4
DOIs
StatePublished - Apr 10 2013

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Tissue
Confocal microscopy
Pathogens
Fractionation
Aging of materials

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Satori, C. P., Henderson, M. M., Krautkramer, E. A., Kostal, V., Distefano, M. D., & Arriaga, E. (2013). Bioanalysis of eukaryotic organelles. Chemical Reviews, 113(4), 2733-2811. https://doi.org/10.1021/cr300354g

Bioanalysis of eukaryotic organelles. / Satori, Chad P.; Henderson, Michelle M.; Krautkramer, Elyse A.; Kostal, Vratislav; Distefano, Mark D; Arriaga, Edgar.

In: Chemical Reviews, Vol. 113, No. 4, 10.04.2013, p. 2733-2811.

Research output: Contribution to journalReview article

Satori, CP, Henderson, MM, Krautkramer, EA, Kostal, V, Distefano, MD & Arriaga, E 2013, 'Bioanalysis of eukaryotic organelles', Chemical Reviews, vol. 113, no. 4, pp. 2733-2811. https://doi.org/10.1021/cr300354g
Satori CP, Henderson MM, Krautkramer EA, Kostal V, Distefano MD, Arriaga E. Bioanalysis of eukaryotic organelles. Chemical Reviews. 2013 Apr 10;113(4):2733-2811. https://doi.org/10.1021/cr300354g
Satori, Chad P. ; Henderson, Michelle M. ; Krautkramer, Elyse A. ; Kostal, Vratislav ; Distefano, Mark D ; Arriaga, Edgar. / Bioanalysis of eukaryotic organelles. In: Chemical Reviews. 2013 ; Vol. 113, No. 4. pp. 2733-2811.
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