Bioanalysis of eukaryotic organelles

Chad P. Satori, Michelle M. Henderson, Elyse A. Krautkramer, Vratislav Kostal, Mark D Distefano, Edgar Arriaga

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

The role that organelle analysis has played in understanding biology is studied. Organelle analysis enables a more specific description of the molecular, biochemical, and physiological processes associated with diseases, embryonic development, tissue differentiation, organism aging, disease treatments, and organism response to pathogens. Confocal microscopy has become a routine tool for investigating subcellular organization, organelle networks, and organelle dynamics in cellular and tissue samples. Most organelles have a dynamic, three-dimensional (3D) organization inside the cell, which is tightly connected to their physiological functions. Due to this, a single 2D image inherently limits the information acquired about the distribution of a particular property within the organelle. The combination of subcellular fractionation with 'omic' technologies has become a powerful resource to characterize and catalogue the various subcellular environments in a cell.

Original languageEnglish (US)
Pages (from-to)2733-2811
Number of pages79
JournalChemical Reviews
Volume113
Issue number4
DOIs
StatePublished - Apr 10 2013

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    Satori, C. P., Henderson, M. M., Krautkramer, E. A., Kostal, V., Distefano, M. D., & Arriaga, E. (2013). Bioanalysis of eukaryotic organelles. Chemical Reviews, 113(4), 2733-2811. https://doi.org/10.1021/cr300354g