Bioactive polybrominated diphenyl ethers from the marine sponge Dysidea sp.

Hui Zhang, Andrew J Skildum, Emily Stromquist, Teresa Rose-Hellekant, Chee Chang Leng

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


A new polybrominated diphenyl ether (9), together with eight known compounds, were isolated from the crude organic extract of the marine sponge Dysidea sp. collected from the Federated States of Micronesia. Their structures were elucidated on the basis of various NMR spectroscopic data. These compounds exhibited inhibitory activities against Streptomyces 85E in the hyphae formation inhibition (HFI) assay and displayed antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7. Compound 6 was selected for further evaluation in a cell cycle progression study.

Original languageEnglish (US)
Pages (from-to)262-264
Number of pages3
JournalJournal of Natural Products
Issue number2
StatePublished - Feb 2008


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