Bio-inspired patterned networks (BIPS) for development of wearable/disposable biosensors

E. S. Mclamore, M. Convertino, John Hondred, Suprem Das, J. C. Claussen, D. C. Vanegas, C. Gomes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Here we demonstrate a novel approach for fabricating point of care (POC) wearable electrochemical biosensors based on 3D patterning of bionanocomposite networks. To create Bio-Inspired Patterned network (BIPS) electrodes, we first generate fractal network in silico models that optimize transport of network fluxes according to an energy function. Network patterns are then inkjet printed onto flexible substrate using conductive graphene ink. We then deposit fractal nanometal structures onto the graphene to create a 3D nanocomposite network. Finally, we biofunctionalize the surface with biorecognition agents using covalent bonding. In this paper, BIPS are used to develop high efficiency, low cost biosensors for measuring glucose as a proof of concept. Our results on the fundamental performance of BIPS sensors show that the biomimetic nanostructures significantly enhance biosensor sensitivity, accuracy, response time, limit of detection, and hysteresis compared to conventional POC non fractal electrodes (serpentine, interdigitated, and screen printed electrodes). BIPs, in particular Apollonian patterned BIPS, represent a new generation of POC biosensors based on nanoscale and microscale fractal networks that significantly improve electrical connectivity, leading to enhanced sensor performance.

Original languageEnglish (US)
Title of host publicationSmart Biomedical and Physiological Sensor Technology XIII
EditorsDouglas Kiehl, Brian M. Cullum, Eric S. McLamore
PublisherSPIE
ISBN (Electronic)9781510601048
DOIs
StatePublished - Jan 1 2016
EventSmart Biomedical and Physiological Sensor Technology XIII - Baltimore, United States
Duration: Apr 18 2016Apr 19 2016

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9863
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceSmart Biomedical and Physiological Sensor Technology XIII
CountryUnited States
CityBaltimore
Period4/18/164/19/16

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    Mclamore, E. S., Convertino, M., Hondred, J., Das, S., Claussen, J. C., Vanegas, D. C., & Gomes, C. (2016). Bio-inspired patterned networks (BIPS) for development of wearable/disposable biosensors. In D. Kiehl, B. M. Cullum, & E. S. McLamore (Eds.), Smart Biomedical and Physiological Sensor Technology XIII [986309] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 9863). SPIE. https://doi.org/10.1117/12.2223345