Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV

Daniel Kronemann, Stacy R. Hagemeier, Dan Cygnar, Stacia Phillips, Wade A. Bresnahan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The human cytomegalovirus (HCMV) tegument protein UL69 is important for efficient viral replication at low multiplicities of infection. Several molecular mechanisms by which UL69 contributes to HCMV replication have been proposed, including UL69's ability to interact with the mRNA export factors UAP56 and URH49 to facilitate the shuttling of viral mRNAs from the nuclei of infected cells. Using a UL69 viral mutant that is unable to bind UAP56 and URH49, we demonstrated that UL69's interaction with UAP56 or URH49 does not contribute to the growth phenotype associated with the UL69 deletion mutant.

Original languageEnglish (US)
Pages (from-to)9649-9654
Number of pages6
JournalJournal of virology
Volume84
Issue number18
DOIs
StatePublished - Sep 2010

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