Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats

J. K. Furne; F. L. Suarez; S. L. Ewing; J. Springfield; M. D. Levitt

doi:10.1023/A:1005580709390

Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats

J. K. Furne, F. L. Suarez, S. L. Ewing, J. Springfield, M. D. Levitt

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Several lines of evidence suggest that ulcerative colitis could be caused by excessive bacterial production of H₂S in the colon. A rodent model of colitis involves the feeding of nonabsorbable, carbohydrate-bound sulfate in the form of dextran sulfate or carrageenan. The observation that metronidazole blocks the development of this colitis suggested that the injurious agent could be a sulfur-containing compound (such as H₂S) that is released during the bacterial metabolism of the nonabsorbed sulfate. We tested this possibility by feeding rats dextran sulfate, with or without bismuth subsalicylate, a compound that avidly binds H₂S. Bismuth subsalicylate reduced the fecal release of H₂S in dextran sulfate-treated rats to values well below that of controls. Nevertheless, all the animals developed colitis. We conclude that excessive H₂S production does not play a role in the dextran sulfate model of colitis.

Original language	English (US)
Pages (from-to)	1439-1443
Number of pages	5
Journal	Digestive Diseases and Sciences
Volume	45
Issue number	7
DOIs	https://doi.org/10.1023/A:1005580709390
State	Published - 2000
Externally published	Yes

Bibliographical note

Funding Information:
Manuscript received September 24, 1998; revised manuscript received February 26, 1999; accepted March 10, 1999. From the Research Service, Minneapolis VA Medical Center, 1 Veterans Drive, Minneapolis, Minnesota 55417. Supported in part by the Department of Veterans Affairs and The National Institute of Diabetes and Digestive and Kidney Diseases grant R01 DK 13309-25. Address for reprint requests: Dr. Michael D. Levitt, Mpls VAMC (151), 1 Veterans Drive, Minneapolis, Minnesota 55417.

Keywords

Bismuth
Colitis
Hydrogen sulfide
Rats

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title = "Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats",

abstract = "Several lines of evidence suggest that ulcerative colitis could be caused by excessive bacterial production of H2S in the colon. A rodent model of colitis involves the feeding of nonabsorbable, carbohydrate-bound sulfate in the form of dextran sulfate or carrageenan. The observation that metronidazole blocks the development of this colitis suggested that the injurious agent could be a sulfur-containing compound (such as H2S) that is released during the bacterial metabolism of the nonabsorbed sulfate. We tested this possibility by feeding rats dextran sulfate, with or without bismuth subsalicylate, a compound that avidly binds H2S. Bismuth subsalicylate reduced the fecal release of H2S in dextran sulfate-treated rats to values well below that of controls. Nevertheless, all the animals developed colitis. We conclude that excessive H2S production does not play a role in the dextran sulfate model of colitis.",

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author = "Furne, {J. K.} and Suarez, {F. L.} and Ewing, {S. L.} and J. Springfield and Levitt, {M. D.}",

note = "Funding Information: Manuscript received September 24, 1998; revised manuscript received February 26, 1999; accepted March 10, 1999. From the Research Service, Minneapolis VA Medical Center, 1 Veterans Drive, Minneapolis, Minnesota 55417. Supported in part by the Department of Veterans Affairs and The National Institute of Diabetes and Digestive and Kidney Diseases grant R01 DK 13309-25. Address for reprint requests: Dr. Michael D. Levitt, Mpls VAMC (151), 1 Veterans Drive, Minneapolis, Minnesota 55417.",

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AU - Furne, J. K.

AU - Suarez, F. L.

AU - Ewing, S. L.

AU - Springfield, J.

AU - Levitt, M. D.

N1 - Funding Information: Manuscript received September 24, 1998; revised manuscript received February 26, 1999; accepted March 10, 1999. From the Research Service, Minneapolis VA Medical Center, 1 Veterans Drive, Minneapolis, Minnesota 55417. Supported in part by the Department of Veterans Affairs and The National Institute of Diabetes and Digestive and Kidney Diseases grant R01 DK 13309-25. Address for reprint requests: Dr. Michael D. Levitt, Mpls VAMC (151), 1 Veterans Drive, Minneapolis, Minnesota 55417.

PY - 2000

Y1 - 2000

N2 - Several lines of evidence suggest that ulcerative colitis could be caused by excessive bacterial production of H2S in the colon. A rodent model of colitis involves the feeding of nonabsorbable, carbohydrate-bound sulfate in the form of dextran sulfate or carrageenan. The observation that metronidazole blocks the development of this colitis suggested that the injurious agent could be a sulfur-containing compound (such as H2S) that is released during the bacterial metabolism of the nonabsorbed sulfate. We tested this possibility by feeding rats dextran sulfate, with or without bismuth subsalicylate, a compound that avidly binds H2S. Bismuth subsalicylate reduced the fecal release of H2S in dextran sulfate-treated rats to values well below that of controls. Nevertheless, all the animals developed colitis. We conclude that excessive H2S production does not play a role in the dextran sulfate model of colitis.

AB - Several lines of evidence suggest that ulcerative colitis could be caused by excessive bacterial production of H2S in the colon. A rodent model of colitis involves the feeding of nonabsorbable, carbohydrate-bound sulfate in the form of dextran sulfate or carrageenan. The observation that metronidazole blocks the development of this colitis suggested that the injurious agent could be a sulfur-containing compound (such as H2S) that is released during the bacterial metabolism of the nonabsorbed sulfate. We tested this possibility by feeding rats dextran sulfate, with or without bismuth subsalicylate, a compound that avidly binds H2S. Bismuth subsalicylate reduced the fecal release of H2S in dextran sulfate-treated rats to values well below that of controls. Nevertheless, all the animals developed colitis. We conclude that excessive H2S production does not play a role in the dextran sulfate model of colitis.

KW - Bismuth

KW - Colitis

KW - Hydrogen sulfide

KW - Rats

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Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats

Abstract

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