The degree of binding (K(s)) of ten 5-ethyl-5-alkyl barbiturates to hepataic microsomal cytochrome P-450 was correlated with lipophilicity (log P, octanol-water) and three information-theoretic topological indices. The theoretically-derived indices were found to be as effective as log P in predicting the K(s) values of barbiturates.
|Original language||English (US)|
|Number of pages||2|
|Journal||Medical Science Research|
|State||Published - Jan 1 1988|