Binding of barbiturates to cytochrome P450: A QSAR study using log P and topological indices

Subhash C Basak

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The degree of binding (K(s)) of ten 5-ethyl-5-alkyl barbiturates to hepataic microsomal cytochrome P-450 was correlated with lipophilicity (log P, octanol-water) and three information-theoretic topological indices. The theoretically-derived indices were found to be as effective as log P in predicting the K(s) values of barbiturates.

Original languageEnglish (US)
Pages (from-to)281-282
Number of pages2
JournalMedical Science Research
Volume16
Issue number6
StatePublished - Jan 1 1988

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