Abstract
The degree of binding (K(s)) of ten 5-ethyl-5-alkyl barbiturates to hepataic microsomal cytochrome P-450 was correlated with lipophilicity (log P, octanol-water) and three information-theoretic topological indices. The theoretically-derived indices were found to be as effective as log P in predicting the K(s) values of barbiturates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-282 |
| Number of pages | 2 |
| Journal | Medical Science Research |
| Volume | 16 |
| Issue number | 6 |
| State | Published - Jan 1 1988 |