TY - JOUR
T1 - BINDING OF 5‐HYDROXYTRYPTAMINE TO ACIDIC LIPIDS IN AN AQUEOUS MEDIUM
AU - Johnson, D. A.
AU - Merlone, S. C.
AU - Loh, H. H.
AU - Ellman, G. L.
PY - 1978/9
Y1 - 1978/9
N2 - The affinities of 5‐hydroxy‐[3H]tryptamine (5‐HT) for cerebroside sulfate, 1‐phosphatidylinositol, 1‐phosphatidylinositol 4‐phosphate, 1‐phosphatidylinositol 4,5‐bisphosphate, phosphatidic acid, and phosphatidyl serine were determined in an aqueous medium. They were observed to be, in general, much lower than and poorly correlated with the values previously reported by Johnsonet al (1977a), measured in isobutanol. This suggested that these lipids probably are not 5‐HT receptors and that drug affinities measured in organic media must be evaluated with caution.
AB - The affinities of 5‐hydroxy‐[3H]tryptamine (5‐HT) for cerebroside sulfate, 1‐phosphatidylinositol, 1‐phosphatidylinositol 4‐phosphate, 1‐phosphatidylinositol 4,5‐bisphosphate, phosphatidic acid, and phosphatidyl serine were determined in an aqueous medium. They were observed to be, in general, much lower than and poorly correlated with the values previously reported by Johnsonet al (1977a), measured in isobutanol. This suggested that these lipids probably are not 5‐HT receptors and that drug affinities measured in organic media must be evaluated with caution.
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U2 - 10.1111/j.1471-4159.1978.tb07845.x
DO - 10.1111/j.1471-4159.1978.tb07845.x
M3 - Article
C2 - 681949
AN - SCOPUS:0017826432
SN - 0022-3042
VL - 31
SP - 713
EP - 717
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 3
ER -