The affinities of 5‐hydroxy‐[3H]tryptamine (5‐HT) for cerebroside sulfate, 1‐phosphatidylinositol, 1‐phosphatidylinositol 4‐phosphate, 1‐phosphatidylinositol 4,5‐bisphosphate, phosphatidic acid, and phosphatidyl serine were determined in an aqueous medium. They were observed to be, in general, much lower than and poorly correlated with the values previously reported by Johnsonet al (1977a), measured in isobutanol. This suggested that these lipids probably are not 5‐HT receptors and that drug affinities measured in organic media must be evaluated with caution.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Neurochemistry|
|State||Published - Sep 1978|