Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice

Keyphrases

• Primary Sclerosing Cholangitis 100%
• Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) 100%
• Biliary Tract 100%
• Smac Mimetics 100%
• Ligand-dependent 100%
• CIAP1 63%
• Cholangiocytes 36%
• Cholangiopathy 36%
• Ligand-receptor Binding 27%
• Bile Duct 27%
• Apoptosis 18%
• Biliary Tract Injuries 18%
• Inflammation 9%
• Liver 9%
• Signaling Pathway 9%
• C57BL 9%
• Gene-deficient Mice 9%
• Antagonism 9%
• Negative Regulator 9%
• Receptor-interacting Protein Kinase 1 (RIPK1) 9%
• Normal Human 9%
• Receptor Signaling 9%
• Protein Level 9%
• Inflammatory Response 9%
• Receptor Agonist 9%
• Non-canonical 9%
• Cholestatic Liver Disease 9%
• Cholestasis 9%
• Systemic Administration 9%
• Inflammatory Chemokines 9%
• NF-B 9%
• Etiopathogenesis 9%
• Serum Markers 9%
• Portal Inflammation 9%
• Cytokine-induced Apoptosis Inhibitor 1 9%
• Chemokine Expression 9%
• Cytokine Expression 9%
• Biliary Epithelial Cells 9%
• TUNEL 9%
• CIAP2 9%
• Biliary Tree 9%
• PANoptosome 9%

Medicine and Dentistry

• Hepatobiliary System 100%
• Sclerosing Cholangitis 100%
• Tumor Necrosis Factor Related Apoptosis Inducing Ligand 100%
• Primary Sclerosing Cholangitis 100%
• Cholangiocyte 66%
• Bile Duct Disease 66%
• down Regulation 50%
• Tumor Necrosis Factor Related Apoptosis Inducing Ligand Receptor 50%
• Programmed Cell Death 33%
• Cytokine 33%
• Bile Duct Injury 33%
• Interlobular Bile Ducts 33%
• Chemokine 33%
• In Vitro 16%
• Cell Signaling Pathway 16%
• Epithelial Cell 16%
• C57BL/6 16%
• Liver Disease 16%
• Systemic Administration 16%
• Upregulation 16%
• Cholestasis 16%
• Bile Duct 16%
• Inhibitor of Apoptosis Protein 16%
• Intrabiliary Drug Administration 16%
• Diseases 16%