Bias voltages at microelectrodes change neural interface properties in vivo

M. D. Johnson, K. J. Otto, J. C. Williams, D. R. Kipke

Research output: Contribution to journalConference articlepeer-review

10 Scopus citations

Abstract

Rejuvenation of iridium microelectrode sites, which involves applying a 1. 5 V bias for 4 s, has been shown to reduce site impedances of chronically implanted microelectrode arrays. This study applied complex impedance spectroscopy measurements to an equivalent circuit model of the electrode-tissue interface. Rejuvenation was found to cause a transient increase in electrode conductivity through an IrO2 layer and a decrease in the surrounding extracellular resistance by 85 ± 1% (n=73, t-test p<0.001) and a decrease in the immediate site resistance by 44 ± 7% (n=73, t-test p<0.001). These findings may be useful as an intervention strategy to prolong the lifetime of chronic microelectrode implants for neuroprostheses.

Original languageEnglish (US)
Pages (from-to)4103-4106
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume26 VI
StatePublished - Dec 1 2004
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Keywords

  • Bias voltage
  • Microelectrodes
  • Neural interface
  • Neuroprostheses
  • Rejuvenation

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