Bias voltages at microelectrodes change neural interface properties in vivo

M. D. Johnson; K. J. Otto; J. C. Williams; D. R. Kipke

Bias voltages at microelectrodes change neural interface properties in vivo

M. D. Johnson, K. J. Otto, J. C. Williams, D. R. Kipke

Biomedical Engineering

Research output: Contribution to journal › Conference article › peer-review

18 Scopus citations

Abstract

Rejuvenation of iridium microelectrode sites, which involves applying a 1. 5 V bias for 4 s, has been shown to reduce site impedances of chronically implanted microelectrode arrays. This study applied complex impedance spectroscopy measurements to an equivalent circuit model of the electrode-tissue interface. Rejuvenation was found to cause a transient increase in electrode conductivity through an IrO₂ layer and a decrease in the surrounding extracellular resistance by 85 ± 1% (n=73, t-test p<0.001) and a decrease in the immediate site resistance by 44 ± 7% (n=73, t-test p<0.001). These findings may be useful as an intervention strategy to prolong the lifetime of chronic microelectrode implants for neuroprostheses.

Original language	English (US)
Pages (from-to)	4103-4106
Number of pages	4
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	26 VI
State	Published - Dec 1 2004
Event	Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States Duration: Sep 1 2004 → Sep 5 2004

Keywords

Bias voltage
Microelectrodes
Neural interface
Neuroprostheses
Rejuvenation

Find It

Find It at U of M Libraries

Cite this

@article{8aa143368f284a97ad3eabf07f531afb,

title = "Bias voltages at microelectrodes change neural interface properties in vivo",

abstract = "Rejuvenation of iridium microelectrode sites, which involves applying a 1. 5 V bias for 4 s, has been shown to reduce site impedances of chronically implanted microelectrode arrays. This study applied complex impedance spectroscopy measurements to an equivalent circuit model of the electrode-tissue interface. Rejuvenation was found to cause a transient increase in electrode conductivity through an IrO2 layer and a decrease in the surrounding extracellular resistance by 85 ± 1% (n=73, t-test p<0.001) and a decrease in the immediate site resistance by 44 ± 7% (n=73, t-test p<0.001). These findings may be useful as an intervention strategy to prolong the lifetime of chronic microelectrode implants for neuroprostheses.",

keywords = "Bias voltage, Microelectrodes, Neural interface, Neuroprostheses, Rejuvenation",

author = "Johnson, {M. D.} and Otto, {K. J.} and Williams, {J. C.} and Kipke, {D. R.}",

year = "2004",

month = dec,

day = "1",

language = "English (US)",

volume = "26 VI",

pages = "4103--4106",

journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

issn = "0589-1019",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 ; Conference date: 01-09-2004 Through 05-09-2004",

}

TY - JOUR

T1 - Bias voltages at microelectrodes change neural interface properties in vivo

AU - Johnson, M. D.

AU - Otto, K. J.

AU - Williams, J. C.

AU - Kipke, D. R.

PY - 2004/12/1

Y1 - 2004/12/1

N2 - Rejuvenation of iridium microelectrode sites, which involves applying a 1. 5 V bias for 4 s, has been shown to reduce site impedances of chronically implanted microelectrode arrays. This study applied complex impedance spectroscopy measurements to an equivalent circuit model of the electrode-tissue interface. Rejuvenation was found to cause a transient increase in electrode conductivity through an IrO2 layer and a decrease in the surrounding extracellular resistance by 85 ± 1% (n=73, t-test p<0.001) and a decrease in the immediate site resistance by 44 ± 7% (n=73, t-test p<0.001). These findings may be useful as an intervention strategy to prolong the lifetime of chronic microelectrode implants for neuroprostheses.

AB - Rejuvenation of iridium microelectrode sites, which involves applying a 1. 5 V bias for 4 s, has been shown to reduce site impedances of chronically implanted microelectrode arrays. This study applied complex impedance spectroscopy measurements to an equivalent circuit model of the electrode-tissue interface. Rejuvenation was found to cause a transient increase in electrode conductivity through an IrO2 layer and a decrease in the surrounding extracellular resistance by 85 ± 1% (n=73, t-test p<0.001) and a decrease in the immediate site resistance by 44 ± 7% (n=73, t-test p<0.001). These findings may be useful as an intervention strategy to prolong the lifetime of chronic microelectrode implants for neuroprostheses.

KW - Bias voltage

KW - Microelectrodes

KW - Neural interface

KW - Neuroprostheses

KW - Rejuvenation

UR - http://www.scopus.com/inward/record.url?scp=11144338209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144338209&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:11144338209

SN - 0589-1019

VL - 26 VI

SP - 4103

EP - 4106

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

T2 - Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004

Y2 - 1 September 2004 through 5 September 2004

ER -

Bias voltages at microelectrodes change neural interface properties in vivo

Abstract

Keywords

Find It

Other files and links

Fingerprint

Cite this