Beyond the ribosome: Extra-translational functions of tRNA fragments

Kevin W Diebel, Kun Zhou, Aaron B. Clarke, Lynne T Bemis

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

High-throughput sequencing studies of small RNAs reveal a complex milieu of noncoding RNAs in biological samples. Early data analysis was often limited to microRNAs due to their regulatory nature and potential as biomarkers; however, many more classes of noncoding RNAs are now being recognized. A class of fragments initially excluded from analysis were those derived from transfer RNAs (tRNAs) because they were thought to be degrada-tion products. More recently, critical cellular function has been attributed to tRNA fragments (tRFs), and their conservation across all domains of life has propelled them into an emerging area of scientific study. The biogenesis of tRFs is currently being elucidated, and initial studies show that a diverse array of tRFs are generated from all parts of a tRNA molecule. The goal of this review was to present what is currently known about tRFs and their potential as biomarkers for the earlier detection of disease.

Original languageEnglish (US)
JournalBiomarker Insights
Volume11
DOIs
StatePublished - Jan 28 2016

Fingerprint

Transfer RNA
Ribosomes
Untranslated RNA
Biomarkers
MicroRNAs
Early Diagnosis
Conservation
Throughput
RNA
Molecules

Keywords

  • Angiogenin
  • Cancer
  • tRFs
  • tRNA biomarkers
  • tRNA fragments

Cite this

Beyond the ribosome : Extra-translational functions of tRNA fragments. / Diebel, Kevin W; Zhou, Kun; Clarke, Aaron B.; Bemis, Lynne T.

In: Biomarker Insights, Vol. 11, 28.01.2016.

Research output: Contribution to journalArticle

@article{d01d69f58deb4edebab5a9ed594408d7,
title = "Beyond the ribosome: Extra-translational functions of tRNA fragments",
abstract = "High-throughput sequencing studies of small RNAs reveal a complex milieu of noncoding RNAs in biological samples. Early data analysis was often limited to microRNAs due to their regulatory nature and potential as biomarkers; however, many more classes of noncoding RNAs are now being recognized. A class of fragments initially excluded from analysis were those derived from transfer RNAs (tRNAs) because they were thought to be degrada-tion products. More recently, critical cellular function has been attributed to tRNA fragments (tRFs), and their conservation across all domains of life has propelled them into an emerging area of scientific study. The biogenesis of tRFs is currently being elucidated, and initial studies show that a diverse array of tRFs are generated from all parts of a tRNA molecule. The goal of this review was to present what is currently known about tRFs and their potential as biomarkers for the earlier detection of disease.",
keywords = "Angiogenin, Cancer, tRFs, tRNA biomarkers, tRNA fragments",
author = "Diebel, {Kevin W} and Kun Zhou and Clarke, {Aaron B.} and Bemis, {Lynne T}",
year = "2016",
month = "1",
day = "28",
doi = "10.4137/BMI.S35904",
language = "English (US)",
volume = "11",
journal = "Biomarker Insights",
issn = "1177-2719",
publisher = "Libertas Academica Ltd.",

}

TY - JOUR

T1 - Beyond the ribosome

T2 - Extra-translational functions of tRNA fragments

AU - Diebel, Kevin W

AU - Zhou, Kun

AU - Clarke, Aaron B.

AU - Bemis, Lynne T

PY - 2016/1/28

Y1 - 2016/1/28

N2 - High-throughput sequencing studies of small RNAs reveal a complex milieu of noncoding RNAs in biological samples. Early data analysis was often limited to microRNAs due to their regulatory nature and potential as biomarkers; however, many more classes of noncoding RNAs are now being recognized. A class of fragments initially excluded from analysis were those derived from transfer RNAs (tRNAs) because they were thought to be degrada-tion products. More recently, critical cellular function has been attributed to tRNA fragments (tRFs), and their conservation across all domains of life has propelled them into an emerging area of scientific study. The biogenesis of tRFs is currently being elucidated, and initial studies show that a diverse array of tRFs are generated from all parts of a tRNA molecule. The goal of this review was to present what is currently known about tRFs and their potential as biomarkers for the earlier detection of disease.

AB - High-throughput sequencing studies of small RNAs reveal a complex milieu of noncoding RNAs in biological samples. Early data analysis was often limited to microRNAs due to their regulatory nature and potential as biomarkers; however, many more classes of noncoding RNAs are now being recognized. A class of fragments initially excluded from analysis were those derived from transfer RNAs (tRNAs) because they were thought to be degrada-tion products. More recently, critical cellular function has been attributed to tRNA fragments (tRFs), and their conservation across all domains of life has propelled them into an emerging area of scientific study. The biogenesis of tRFs is currently being elucidated, and initial studies show that a diverse array of tRFs are generated from all parts of a tRNA molecule. The goal of this review was to present what is currently known about tRFs and their potential as biomarkers for the earlier detection of disease.

KW - Angiogenin

KW - Cancer

KW - tRFs

KW - tRNA biomarkers

KW - tRNA fragments

UR - http://www.scopus.com/inward/record.url?scp=84961833423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961833423&partnerID=8YFLogxK

U2 - 10.4137/BMI.S35904

DO - 10.4137/BMI.S35904

M3 - Article

C2 - 26843810

AN - SCOPUS:84961833423

VL - 11

JO - Biomarker Insights

JF - Biomarker Insights

SN - 1177-2719

ER -