Betweenness Centrality in Resting-State Functional Networks Distinguishes Parkinson's Disease

Satya Venkata Sandeep Avvaru, Keshab K. Parhi

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The goal of this paper is to use graph theory network measures derived from non-invasive electroencephalography (EEG) to develop neural decoders that can differentiate Parkinson's disease (PD) patients from healthy controls (HC). EEG signals from 27 patients and 27 demographically matched controls from New Mexico were analyzed by estimating their functional networks. Data recorded from the patients during ON and OFF levodopa sessions were included in the analysis for comparison. We used betweenness centrality of estimated functional networks to classify the HC and PD groups. The classifiers were evaluated using leave-one-out cross-validation. We observed that the PD patients (on and off medication) could be distinguished from healthy controls with 89% accuracy - approximately 4% higher than the state-of-the-art on the same dataset. This work shows that brain network analysis using extracranial resting-state EEG can discover patterns of interactions indicative of PD. This approach can also be extended to other neurological disorders.

Bibliographical note

Funding Information:
This research was supported in part by the National Science Foundation under grant number CCF-1954749.

Publisher Copyright:
© 2022 IEEE.

PubMed: MeSH publication types

  • Journal Article
  • Research Support, U.S. Gov't, Non-P.H.S.


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