Beta-cell replacement therapy: Current outcomes and future landscape

Ty B. Dunn, Varvara Kirchner, Melena D. Bellin

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Purpose of review This article provides a summary of the current outcomes of b-cell replacement strategies, an algorithm for choosing a specific modality while highlighting associated advantages and disadvantages, and outlines remaining challenges and areas of active investigation in b-cell replacement therapy. Recent findings The most recent reports of islet cell allotransplantation have shown improvements over previous eras and now rival some outcomes of pancreas alone transplantation. Active areas of investigation are focused on improving techniques for islet isolation, graft monitoring, and managing challenges posed by the innate and alloimmune systems. Summary Patients with insulin-dependent diabetes who continue to experience life threatening hypoglycemia despite maximal medical management can benefit from b-cell replacement. Emerging nontransplant technologies have not provided a physiologic euglycemic state to the extent offered by transplantation. Islet transplantation eliminates hypoglycemic episodes/unawareness, facilitates normalization of hemoglobin A1c (HbA1c), decreases microvascular disease progression, and improves quality of life for patients with problematic diabetes. Mid-and long-term outcomes of islet transplantation performed at expert centers approximate those of registry reports of solitary pancreas transplant, whereas the complication profile is quite favorable.

Original languageEnglish (US)
Pages (from-to)681-690
Number of pages10
JournalCurrent Opinion in Organ Transplantation
Issue number6
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. All rights reserved.


  • Allotransplant
  • Autotransplant
  • Islet cell
  • Outcomes
  • Pancreas transplant


Dive into the research topics of 'Beta-cell replacement therapy: Current outcomes and future landscape'. Together they form a unique fingerprint.

Cite this