Bench-to-bedside review: Microvascular and airspace linkage in ventilator-induced lung injury

John J Marini, John R. Hotchkiss, Alain F Broccard

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations


Experimental and clinical evidence point strongly toward the potential for microvascular stresses to influence the severity and expression of ventilator associated lung injury. Intense microvascular stresses not only influence edema but predispose to structural failure of the gas-blood barrier, possibly with adverse consequences for the lung and for extrapulmonary organs. Taking measures to lower vascular stress may offer a logical, but as yet unproven, extension of a lung-protective strategy for life support in ARDS.

Original languageEnglish (US)
Pages (from-to)435-444
Number of pages10
JournalCritical Care
Issue number6
StatePublished - Dec 2003


  • Acute respiratory distress syndrome
  • Capillary stress fracture
  • Mechanical ventilation
  • Vascular injury
  • Ventilator-induced lung injury


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