Abstract
Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 382-387 |
| Number of pages | 6 |
| Journal | Behavioural Brain Research |
| Volume | 225 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 20 2011 |
| Externally published | Yes |
Bibliographical note
Funding Information:This research was supported by a grant from the Health Research Council of New Zealand . We would also like to thank Saralee Illingworth for her involvement.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
Keywords
- Context
- Immune
- Memory
- Rat
- Reversal
- Schizophrenia
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