Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.
Bibliographical noteFunding Information:
This research was supported by a grant from the Health Research Council of New Zealand . We would also like to thank Saralee Illingworth for her involvement.
Copyright 2012 Elsevier B.V., All rights reserved.