Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia

Amy R. Wolff; Kirsten R. Cheyne; David K. Bilkey

doi:10.1016/j.bbr.2011.07.033

Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia

Amy R. Wolff, Kirsten R. Cheyne, David K. Bilkey

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.

Original language	English (US)
Pages (from-to)	382-387
Number of pages	6
Journal	Behavioural Brain Research
Volume	225
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2011.07.033
State	Published - Nov 20 2011
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by a grant from the Health Research Council of New Zealand . We would also like to thank Saralee Illingworth for her involvement.

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

Context
Immune
Memory
Rat
Reversal
Schizophrenia

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10.1016/j.bbr.2011.07.033

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abstract = "Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.",

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AU - Cheyne, Kirsten R.

AU - Bilkey, David K.

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PY - 2011/11/20

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N2 - Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.

AB - Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.

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Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia

Abstract

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Keywords

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