Behavioral interactions between naloxone and dopamine agonists

R. Adron Harris, Diane Snell, Horace H. Loh, E. Leong Way

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

A fixed-interval schedule of food presentation was used to study the effects of apomorphine, ET-495 and clonidine and interactions between these drugs and naloxone in the rat. The rate of responding under this schedule was decreased by low doses of apomorphine (0.03-0.3 mg/kg), ET-495 (0.3-1.0 mg/kg) and clonidine (0.03-0.3 mg/kg). Naloxone, at a dose (3 mg/kg) which did not itself alter responding, potentiated the rate decreasing effects of apomorphine and ET-495 but did not alter the effects of clonidine. It is suggested that the rate decreasing effects of low doses of apomorphine and ET-495 may be related to presynaptic inhibition of dopamine neurons and that under certain circumstances naloxone may also inhibit dopaminergic activity.

Original languageEnglish (US)
Pages (from-to)243-246
Number of pages4
JournalEuropean Journal of Pharmacology
Volume43
Issue number3
DOIs
StatePublished - Jun 1 1977

Keywords

  • Clonidine
  • Dopamine agonists
  • Naloxone
  • Schedule-controlled behavior

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