Behavioral interactions between naloxone and dopamine agonists

R. Adron Harris; Diane Snell; Horace H. Loh; E. Leong Way

doi:10.1016/0014-2999(77)90023-1

Behavioral interactions between naloxone and dopamine agonists

R. Adron Harris, Diane Snell, Horace H. Loh, E. Leong Way

Pharmacology

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A fixed-interval schedule of food presentation was used to study the effects of apomorphine, ET-495 and clonidine and interactions between these drugs and naloxone in the rat. The rate of responding under this schedule was decreased by low doses of apomorphine (0.03-0.3 mg/kg), ET-495 (0.3-1.0 mg/kg) and clonidine (0.03-0.3 mg/kg). Naloxone, at a dose (3 mg/kg) which did not itself alter responding, potentiated the rate decreasing effects of apomorphine and ET-495 but did not alter the effects of clonidine. It is suggested that the rate decreasing effects of low doses of apomorphine and ET-495 may be related to presynaptic inhibition of dopamine neurons and that under certain circumstances naloxone may also inhibit dopaminergic activity.

Original language	English (US)
Pages (from-to)	243-246
Number of pages	4
Journal	European Journal of Pharmacology
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(77)90023-1
State	Published - Jun 1 1977

Bibliographical note

Funding Information:
* Supported an part by grants DA-02785 and DA-00564 from the NIDA ** Present address Department of Pharmacology, Umversity of Missouri Medmal Center, Columbm, Mo 65201, U S A

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

Clonidine
Dopamine agonists
Naloxone
Schedule-controlled behavior

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10.1016/0014-2999(77)90023-1

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title = "Behavioral interactions between naloxone and dopamine agonists",

abstract = "A fixed-interval schedule of food presentation was used to study the effects of apomorphine, ET-495 and clonidine and interactions between these drugs and naloxone in the rat. The rate of responding under this schedule was decreased by low doses of apomorphine (0.03-0.3 mg/kg), ET-495 (0.3-1.0 mg/kg) and clonidine (0.03-0.3 mg/kg). Naloxone, at a dose (3 mg/kg) which did not itself alter responding, potentiated the rate decreasing effects of apomorphine and ET-495 but did not alter the effects of clonidine. It is suggested that the rate decreasing effects of low doses of apomorphine and ET-495 may be related to presynaptic inhibition of dopamine neurons and that under certain circumstances naloxone may also inhibit dopaminergic activity.",

keywords = "Clonidine, Dopamine agonists, Naloxone, Schedule-controlled behavior",

author = "Harris, {R. Adron} and Diane Snell and Loh, {Horace H.} and Way, {E. Leong}",

note = "Funding Information: * Supported an part by grants DA-02785 and DA-00564 from the NIDA ** Present address Department of Pharmacology, Umversity of Missouri Medmal Center, Columbm, Mo 65201, U S A Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1977",

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doi = "10.1016/0014-2999(77)90023-1",

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T1 - Behavioral interactions between naloxone and dopamine agonists

AU - Harris, R. Adron

AU - Snell, Diane

AU - Loh, Horace H.

AU - Way, E. Leong

N1 - Funding Information: * Supported an part by grants DA-02785 and DA-00564 from the NIDA ** Present address Department of Pharmacology, Umversity of Missouri Medmal Center, Columbm, Mo 65201, U S A Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1977/6/1

Y1 - 1977/6/1

N2 - A fixed-interval schedule of food presentation was used to study the effects of apomorphine, ET-495 and clonidine and interactions between these drugs and naloxone in the rat. The rate of responding under this schedule was decreased by low doses of apomorphine (0.03-0.3 mg/kg), ET-495 (0.3-1.0 mg/kg) and clonidine (0.03-0.3 mg/kg). Naloxone, at a dose (3 mg/kg) which did not itself alter responding, potentiated the rate decreasing effects of apomorphine and ET-495 but did not alter the effects of clonidine. It is suggested that the rate decreasing effects of low doses of apomorphine and ET-495 may be related to presynaptic inhibition of dopamine neurons and that under certain circumstances naloxone may also inhibit dopaminergic activity.

AB - A fixed-interval schedule of food presentation was used to study the effects of apomorphine, ET-495 and clonidine and interactions between these drugs and naloxone in the rat. The rate of responding under this schedule was decreased by low doses of apomorphine (0.03-0.3 mg/kg), ET-495 (0.3-1.0 mg/kg) and clonidine (0.03-0.3 mg/kg). Naloxone, at a dose (3 mg/kg) which did not itself alter responding, potentiated the rate decreasing effects of apomorphine and ET-495 but did not alter the effects of clonidine. It is suggested that the rate decreasing effects of low doses of apomorphine and ET-495 may be related to presynaptic inhibition of dopamine neurons and that under certain circumstances naloxone may also inhibit dopaminergic activity.

KW - Clonidine

KW - Dopamine agonists

KW - Naloxone

KW - Schedule-controlled behavior

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

Behavioral interactions between naloxone and dopamine agonists

Abstract

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