Behavioral Effects of Tricyclic Drugs in Depressed Inpatients

John S. Lyons, Alexander J. Rosen, Maurice W. Dysken

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A bivariate model of response to antidepressant medication (tricyclic) and psychosocial interventions is proposed and a specific test of the drug response aspect of this model was designed, using objectively defined nonpathognomonic behaviors. Repeated measures analyses of variance and interrupted time-series analyses were used to test whether tricyclics affected different constellations of behaviors in depressed inpatients. Results showed that drug interventions increased the frequencies of activity-related behaviors only. However, positive clinical response was related to elevated levels of both activity-related and interpersonal behaviors. The implications of these results for the treatment of depression and the elucidation of behavioral mechanisms of drug action are discussed.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalJournal of consulting and clinical psychology
Issue number1
StatePublished - Feb 1985


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