Behavioral disinhibition in mice bred for high drinking in the dark (HDID) and HS controls increases following ethanol

Megan E. Tipps, Travis M. Moschak, Suzanne H. Mitchell

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Alcohol consumption and behavioral inhibition share some common underlying genetic mechanisms. The current study examined whether lines of mice selected for high blood ethanol concentrations, attained by heavy drinking in the dark period (DID) of the light-dark cycle that models binge drinking, also exhibit higher levels of drug-naïve inhibition. It also examined whether the administration of ethanol would result in higher levels of disinhibition in these selected lines compared to the founder stock (HS). Methods: A Go/No-Go task was used to assess baseline inhibition and the effects of acute ethanol on disinhibition (response to a No-Go cue) in the HS line and in mice selected for high levels of DID (HDID-1 and HDID-2). Results: Lines did not differ in inhibition at baseline and all lines showed increased disinhibition following moderate doses of ethanol. Ethanol decreased responding to Go cues for HDID-2 and HS lines at high doses but not HDID-1 mice. Conclusions: These data corroborate previous work showing ethanol-induced increases in behavioral disinhibition. The selection paradigm did not result in differential sensitivity to the disinhibiting effects of ethanol, but did result in differential sensitivity to the suppressant effects of ethanol on operant behavior between the two HDID lines.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalDrug and alcohol dependence
Issue number1
StatePublished - Mar 1 2014

Bibliographical note

Funding Information:
This research was supported by the Portland Alcohol Research Center ( P60 AA10760 ). MET was supported by NIAAA F32AA022011 . TMM was supported by NIAAA T32 training grant AA007468 and F31 AA020741 . All research was conducted in compliance with laws in the United States of America.


  • Alcohol
  • Drinking in the dark
  • Go/No-Go
  • Impulsivity
  • Inhibition
  • Selected lines


Dive into the research topics of 'Behavioral disinhibition in mice bred for high drinking in the dark (HDID) and HS controls increases following ethanol'. Together they form a unique fingerprint.

Cite this