Behavioral and physiological characterization of male mice under chronic psychosocial stress

Alessandro Bartolomucci, Tiziana Pederzani, Paola Sacerdote, Alberto E. Panerai, Stefano Parmigiani, Paola Palanza

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


Social stress is a major factor in the etiology of several psychopathologies, with individuals greatly differing in vulnerability. The development of appropriate animal models of social stress is, thus, a major challenge of modern bio-medical research. Adult male mice were subjected to a new model of chronic psychosocial stress in which resident/intruder dyads live chronically in sensory contact and physically interact on a daily basis. Four behavioral categories were identified: Resident Dominants (RD), Resident Subordinates (RS), Intruder Dominants (InD), Intruder Subordinates (InS). Here we investigated: behavior during aggressive interactions; gross physiological components of mice metabolism; organ physiology; response to dexamethasone suppression test (DST). RD and InD mice showed persistently high levels of aggression. All four categories of mice showed robust lack of suppression of corticosterone level when challenged with the DST. Although food intake was not altered under chronic stress, body weight decreased in RD and InD mice while increased in InS and, even more so, in RS mice, suggesting an alteration of their metabolic functions. In conclusion, social status and territory ownership were factors determining individual vulnerability to stress exposure. Our model could, thus, be regarded as a valid model to investigate the biological basis of the individual differences in the response to stressful events.

Original languageEnglish (US)
Pages (from-to)899-910
Number of pages12
Issue number7
StatePublished - Aug 2004

Bibliographical note

Funding Information:
Authors are indebted to Robert M. Sapolsky for a critical revision of the manuscript and, to Elena Choleris for improving the final version. Valeria Vascelli is acknowledged for technical assistance. Aliosha Malcevschi and Lucianne Groenink are acknowledged for kind help provided for the dexamethasone study. Financially supported by Italian MIUR and University of Parma.


  • Animal models
  • Body weight
  • Corticosterone
  • Dexamethasone suppression test
  • Food intake
  • Social status

Fingerprint Dive into the research topics of 'Behavioral and physiological characterization of male mice under chronic psychosocial stress'. Together they form a unique fingerprint.

Cite this