Bee venom acupoint stimulation increases Fos expression in catecholaminergic neurons in the rat brain

Young Bae Kwon, Ho Jae Han, Alvin J. Beitz, Jang Hern Lee

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Fos immunocytochemistry was combined with tyrosine hydroxylase (TH) or dopamine-beta-hydroxylase (DBH) immunolabeling to examine brainstem catecholaminergic neuronal activation resulting from bee venom (BV) stimulation of the Zusanli acupoint (ST36) in Sprague-Dawley rats. BV injection into the Zusanli acupoint caused increased Fos expression in catecholaminergic neurons located in the hypothalamic arcuate nucleus (Arc), the dorsal raphe (DR), the A5 cell group (A5) and the locus coeruleus (LC). BV acupoint stimulation significantly increased Fos-TH double-labeled neurons in the Arc, LC and DR. Fos-DBH positive neurons were also increased by BV acupoint stimulation in the LC and A5. In contrast BV stimulation of a non-acupoint only increased Fos expression and Fos-TH double-labeled neurons in the Arc. These data indicate that BV acupoint stimulation activates brainstem catecholaminergic neurons and that this activation underlies BV acupoint-induced antinociception.

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalMolecules and cells
Volume17
Issue number2
StatePublished - Apr 30 2004

Keywords

  • Acupuncture
  • Bee venom
  • Dopamine-beta-hydroxylase
  • Fos
  • Tyrosine hydroxylase

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