BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

S. Karamohamed; J. C. Latourelle; B. A. Racette; J. S. Perlmutter; G. F. Wooten; M. Lew; C. Klein; H. Shill; L. I. Golbe; M. H. Mark; M. Guttman; G. Nicholson; J. B. Wilk; M. Saint-Hilaire; A. L. DeStefano; R. Prakash; S. Tobin; J. Williamson; O. Suchowersky; N. Labell; B. N.J. Growdon; C. Singer; R. Watts; S. Goldwurm; G. Pezzoli; K. B. Baker; M. L. Giroux; P. P. Pramstaller; D. J. Burn; P. Chinnery; S. Sherman; P. Vieregge; I. Litvan; J. F. Gusella; R. H. Myers; A. Parsian

doi:10.1212/01.wnl.0000187075.81589.fd

BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

S. Karamohamed, J. C. Latourelle, B. A. Racette, J. S. Perlmutter, G. F. Wooten, M. Lew, C. Klein, H. Shill, L. I. Golbe, M. H. Mark, M. Guttman, G. Nicholson, J. B. Wilk, M. Saint-Hilaire, A. L. DeStefano, R. Prakash, S. Tobin, J. Williamson, O. Suchowersky, N. LabellB. N.J. Growdon, C. Singer, R. Watts, S. Goldwurm, G. Pezzoli, K. B. Baker, M. L. Giroux, P. P. Pramstaller, D. J. Burn, P. Chinnery, S. Sherman, P. Vieregge, I. Litvan, J. F. Gusella, R. H. Myers, A. Parsian

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Abstract

Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

Original language	English (US)
Pages (from-to)	1823-1825
Number of pages	3
Journal	Neurology
Volume	65
Issue number	11
DOIs	https://doi.org/10.1212/01.wnl.0000187075.81589.fd
State	Published - Dec 2005
Externally published	Yes

Bibliographical note

Funding Information:
Supported by the Bumpus Foundation, PHS grant R01 NS36711-05 “Genetic Linkage Study in Parkinson’s Disease,” and the Arkansas Bioscience Institute. The DNA samples contributed by the Parkinson Institute–Istituti Clinici di Perfezionamento, Milan, Italy, were from the “Human Genetic Bank of Patients Affected by Parkinson Disease and Parkinsonisms,” supported by Italian Telethon grant no. GTF03009.

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Karamohamed, S., Latourelle, J. C., Racette, B. A., Perlmutter, J. S., Wooten, G. F., Lew, M., Klein, C., Shill, H., Golbe, L. I., Mark, M. H., Guttman, M., Nicholson, G., Wilk, J. B., Saint-Hilaire, M., DeStefano, A. L., Prakash, R., Tobin, S., Williamson, J., Suchowersky, O., ... Parsian, A. (2005). BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study. Neurology, 65(11), 1823-1825. https://doi.org/10.1212/01.wnl.0000187075.81589.fd

Karamohamed, S, Latourelle, JC, Racette, BA, Perlmutter, JS, Wooten, GF, Lew, M, Klein, C, Shill, H, Golbe, LI, Mark, MH, Guttman, M, Nicholson, G, Wilk, JB, Saint-Hilaire, M, DeStefano, AL, Prakash, R, Tobin, S, Williamson, J, Suchowersky, O, Labell, N, Growdon, BNJ, Singer, C, Watts, R, Goldwurm, S, Pezzoli, G, Baker, KB, Giroux, ML, Pramstaller, PP, Burn, DJ, Chinnery, P, Sherman, S, Vieregge, P, Litvan, I, Gusella, JF, Myers, RH & Parsian, A 2005, 'BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study', Neurology, vol. 65, no. 11, pp. 1823-1825. https://doi.org/10.1212/01.wnl.0000187075.81589.fd

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title = "BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study",

abstract = "Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.",

author = "S. Karamohamed and Latourelle, {J. C.} and Racette, {B. A.} and Perlmutter, {J. S.} and Wooten, {G. F.} and M. Lew and C. Klein and H. Shill and Golbe, {L. I.} and Mark, {M. H.} and M. Guttman and G. Nicholson and Wilk, {J. B.} and M. Saint-Hilaire and DeStefano, {A. L.} and R. Prakash and S. Tobin and J. Williamson and O. Suchowersky and N. Labell and Growdon, {B. N.J.} and C. Singer and R. Watts and S. Goldwurm and G. Pezzoli and Baker, {K. B.} and Giroux, {M. L.} and Pramstaller, {P. P.} and Burn, {D. J.} and P. Chinnery and S. Sherman and P. Vieregge and I. Litvan and Gusella, {J. F.} and Myers, {R. H.} and A. Parsian",

note = "Funding Information: Supported by the Bumpus Foundation, PHS grant R01 NS36711-05 “Genetic Linkage Study in Parkinson{\textquoteright}s Disease,” and the Arkansas Bioscience Institute. The DNA samples contributed by the Parkinson Institute–Istituti Clinici di Perfezionamento, Milan, Italy, were from the “Human Genetic Bank of Patients Affected by Parkinson Disease and Parkinsonisms,” supported by Italian Telethon grant no. GTF03009. ",

year = "2005",

month = dec,

doi = "10.1212/01.wnl.0000187075.81589.fd",

language = "English (US)",

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T1 - BDNF genetic variants are associated with onset age of familial Parkinson disease

T2 - GenePD Study

AU - Karamohamed, S.

AU - Latourelle, J. C.

AU - Racette, B. A.

AU - Perlmutter, J. S.

AU - Wooten, G. F.

AU - Lew, M.

AU - Klein, C.

AU - Shill, H.

AU - Golbe, L. I.

AU - Mark, M. H.

AU - Guttman, M.

AU - Nicholson, G.

AU - Wilk, J. B.

AU - Saint-Hilaire, M.

AU - DeStefano, A. L.

AU - Prakash, R.

AU - Tobin, S.

AU - Williamson, J.

AU - Suchowersky, O.

AU - Labell, N.

AU - Growdon, B. N.J.

AU - Singer, C.

AU - Watts, R.

AU - Goldwurm, S.

AU - Pezzoli, G.

AU - Baker, K. B.

AU - Giroux, M. L.

AU - Pramstaller, P. P.

AU - Burn, D. J.

AU - Chinnery, P.

AU - Sherman, S.

AU - Vieregge, P.

AU - Litvan, I.

AU - Gusella, J. F.

AU - Myers, R. H.

AU - Parsian, A.

N1 - Funding Information: Supported by the Bumpus Foundation, PHS grant R01 NS36711-05 “Genetic Linkage Study in Parkinson’s Disease,” and the Arkansas Bioscience Institute. The DNA samples contributed by the Parkinson Institute–Istituti Clinici di Perfezionamento, Milan, Italy, were from the “Human Genetic Bank of Patients Affected by Parkinson Disease and Parkinsonisms,” supported by Italian Telethon grant no. GTF03009.

PY - 2005/12

Y1 - 2005/12

N2 - Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

AB - Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

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SN - 0028-3878

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JO - Neurology

JF - Neurology

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ER -

BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

Abstract

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