Basic research in epilepsy and aging

Ilo E. Leppik; Kevin M. Kelly; Leyla DeToledo-Morrell; Peter R. Patrylo; Robert J. DeLorenzo; Gary W. Mathern; H. Steve White

doi:10.1016/j.eplepsyres.2005.07.014

Basic research in epilepsy and aging

Ilo E. Leppik, Kevin M. Kelly, Leyla DeToledo-Morrell, Peter R. Patrylo, Robert J. DeLorenzo, Gary W. Mathern, H. Steve White

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A PubMed search of the years 1965 to 2003 found only 30 articles that were directly related to modeling seizures or epilepsy in aged animals. This lack of research is disturbing but explainable because of the high cost of aged animals and their increasing infirmity. Many changes occur in the older brain: cell loss in the hippocampal formation, changes in long-term potentiation maintenance, alteration in kindling, increased susceptibility to status epilepticus, and neuronal damage from stroke. The effect of aging on voltage-gated sodium and calcium channels has not been studied sufficiently. With increasing numbers of elderly persons with epilepsy needing appropriate treatment, the need to better understand the basic mechanisms of epilepsy is crucial.

Original language	English (US)
Pages (from-to)	21-37
Number of pages	17
Journal	Epilepsy Research
Volume	68
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/j.eplepsyres.2005.07.014
State	Published - Jan 2006

Keywords

Aging
Animal models
Epilepsy
Kindling
Stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.eplepsyres.2005.07.014

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title = "Basic research in epilepsy and aging",

abstract = "A PubMed search of the years 1965 to 2003 found only 30 articles that were directly related to modeling seizures or epilepsy in aged animals. This lack of research is disturbing but explainable because of the high cost of aged animals and their increasing infirmity. Many changes occur in the older brain: cell loss in the hippocampal formation, changes in long-term potentiation maintenance, alteration in kindling, increased susceptibility to status epilepticus, and neuronal damage from stroke. The effect of aging on voltage-gated sodium and calcium channels has not been studied sufficiently. With increasing numbers of elderly persons with epilepsy needing appropriate treatment, the need to better understand the basic mechanisms of epilepsy is crucial.",

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AU - Leppik, Ilo E.

AU - Kelly, Kevin M.

AU - DeToledo-Morrell, Leyla

AU - Patrylo, Peter R.

AU - DeLorenzo, Robert J.

AU - Mathern, Gary W.

AU - White, H. Steve

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KW - Kindling

KW - Stroke

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Basic research in epilepsy and aging

Abstract

Keywords

UN SDGs

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