Basic Principles in Immunology: Relevance for Studies in Psychoneuroimmunology

Sarah M. Clark, Kerry C. Michael, Achsah D. Keegan, Leonardo H. Tonelli

Research output: Chapter in Book/Report/Conference proceedingChapter


An important focus of the field of neuroimmunology is to elucidate the ways that the immune system influences neuronal function and subsequently, behavior and cognition through the modulation of cytokines and hormones, especially stress hormones such as corticosteroids. This chapter presents an introduction to some basic aspects of immunity and how it relates to brain function and behavior in the context of mental health research. It also presents some models used to study the effects of activation of the immune system on emotional and cognitive function. Cytokines and chemokines are protein and glycoprotein molecules synthesized and secreted by cells as part of the immune response. Two main methods have been widely used in psychoneuroimmunology to elicit an immune response reflected in changes in behavior and/or mental and cognitive functions. It is expected that better models of psychoneuroimmune interaction will highlight complex psychiatric diseases, providing targets of improved intervention for treatment.

Original languageEnglish (US)
Title of host publicationThe Wiley-Blackwell Handbook of Psychoneuroimmunology
Number of pages23
ISBN (Electronic)9781118314814
ISBN (Print)9781119979517
StatePublished - Jan 1 2013
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 John Wiley and Sons, Ltd.


  • Brain
  • Chemokines
  • Cytokines
  • Immunity
  • Mental health
  • Psychoneuroimmunology


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