Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review

Jianyi Zhang, Roberto Bolli, Daniel J. Garry, Eduardo Marbán, Philippe Menasché, Wolfram Hubertus Zimmermann, Timothy J. Kamp, Joseph C. Wu, Victor J. Dzau

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

This paper aims to provide an important update on the recent preclinical and clinical trials using cell therapy strategies and engineered heart tissues for the treatment of postinfarction left ventricular remodeling and heart failure. In addition to the authors’ own works and opinions on the roadblocks of the field, they discuss novel approaches for cardiac remuscularization via the activation of proliferative mechanisms in resident cardiomyocytes or direct reprogramming of somatic cells into cardiomyocytes. This paper's main mindset is to present current and future strategies in light of their implications for the design of future patient trials with the ultimate objective of facilitating the translation of discoveries in regenerative myocardial therapies to the clinic.

Original languageEnglish (US)
Pages (from-to)2092-2105
Number of pages14
JournalJournal of the American College of Cardiology
Volume78
Issue number21
DOIs
StatePublished - Nov 23 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors

Keywords

  • heart
  • heart failure
  • myocardial infarction
  • myocyte proliferation
  • pluripotent stem cell

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