Baseline visual acuity at wet amd diagnosis predicts long-term vision outcomes: An analysis of the iris registry

Allen C. Ho, David M. Kleinman, Flora C. Lum, Jeffrey S. Heier, Richard L. Lindstrom, Susan C. Orr, Grace C. Chang, Eleanor L. Smith, John S. Pollack

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


BACKGROUND AND OBJECTIVE: Clinical trials in neovascular age-related macular degeneration (nAMD) demonstrate that high visual acuity (VA) can be maintained, and low VA can be improved with anti-vascular endothelial growth factor (VEGF) treatment. Few real-world data investigating the relationship between baseline VA and long-term outcomes exist. This study compares VA at diagnosis and after treatment using data from a large patient registry. PATIENTS AND METHODS: Retrospective study of IRIS Registry patients diagnosed with nAMD in one or both eyes between January 2013 and June 2017. Patients received at least two anti-VEGF injections in the study eye(s) less than 45 days apart during the study period. Primary outcomes were the percentage of eyes with 20/40 VA or better at diagnosis and association of VA at diagnosis with longer-term visual outcomes. RESULTS: The study included 162,902 eyes. Among all included eyes, 34.3% presented with 20/40 VA or better at diagnosis. Patients with 20/40 vision or better at baseline maintained a mean VA of 20/40 or better for 2 years after treatment initiation. CONCLUSIONS: Baseline VA at nAMD diagnosis predicts long-term VA outcomes. Early diagnosis before VA is adversely affected is a key factor in preserving vision in patients with nAMD.

Original languageEnglish (US)
Pages (from-to)633-639
Number of pages7
JournalOphthalmic Surgery Lasers and Imaging Retina
Issue number11
StatePublished - Nov 2020

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Publisher Copyright:
© 2020 Ho, Kleinman, Lum, et al.


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