Baseline characteristics of African Americans in the Systolic Blood Pressure Intervention Trial

Carolyn H. Still, Timothy E. Craven, Barry I. Freedman, Peter N. Van Buren, Kaycee M. Sink, Anthony A. Killeen, Jeffrey T. Bates, Alberta Bee, Gabriel Contreras, Suzanne Oparil, Carolyn M. Pedley, Barry M. Wall, Suzanne White, Delia M. Woods, Carlos J. Rodriguez, Jackson T. Wright

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The Systolic Blood Pressure Intervention Trial (SPRINT) will compare treatment to a systolic blood pressure goal of <120 mm Hg to treatment to the currently recommended goal of <140 mm Hg for effects on incident cardiovascular, renal, and neurologic outcomes including cognitive decline. The objectives of this analysis are to compare baseline characteristics of African American (AA) and non-AA SPRINT participants and explore factors associated with uncontrolled blood pressure (BP) by race. SPRINT enrolled 9361 hypertensive participants aged older than 50 years. This cross-sectional analysis examines sociodemographics, baseline characteristics, and study measures among AAs compared with non-AAs. AAs made up 31% of participants. AAs (compared with non-AAs) were younger and less frequently male, had less education, and were more likely uninsured or covered by Medicaid. In addition, AAs scored lower on the cognitive screening test when compared with non-AAs. Multivariate logistic regression analysis found BP control rates to <140/90 mm Hg were higher for AAs who were male, had higher number of chronic diseases, were on diuretic treatment, and had better medication adherence. SPRINT is well poised to examine the effects of systolic blood pressure targets on clinical outcomes as well as predictors influencing BP control in AAs.

Original languageEnglish (US)
Pages (from-to)670-679
Number of pages10
JournalJournal of the American Society of Hypertension
Volume9
Issue number9
DOIs
StatePublished - Sep 1 2015

Bibliographical note

Funding Information:
The Systolic Blood Pressure Intervention Trial is funded with Federal funds from the National Institutes of Health (NIH), including the National Heart, Lung, and Blood Institute (NHLBI), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute on Aging (NIA), and the National Institute of Neurological Disorders and Stroke (NINDS), under Contract Numbers HHSN268200900040C, HHSN268200900046C, HHSN268200900047C, HHSN268200900048C, HHSN268200900049C, and Inter-Agency Agreement Number A-HL-13-002-001. It was also supported in part with resources and use of facilities through the Department of Veterans Affairs. The SPRINT investigators acknowledge the contribution of study medications (azilsartan and azilsartan combined with chlorthalidone) from Takeda Pharmaceuticals Inc. All components of the SPRINT study protocol were designed and implemented by the investigators. The investigative team collected, analyzed, and interpreted the data. All aspects of manuscript writing and revision were carried out by the coauthors. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, the US Department of Veterans Affairs, or the United States Government. For a full list of contributors to SPRINT, please see the supplementary acknowledgement list: ClinicalTrials.gov Identifier: NCT01206062 .

Funding Information:
We also acknowledge the support from the following CTSAs funded by NCATS : CWRU: UL1TR000439 , OSU: UL1RR025755 , U Penn: UL1RR024134 and UL1TR000003 , Boston: UL1RR025771 , Stanford: UL1TR000093 , Tufts: UL1RR025752 , UL1TR000073 , and UL1TR001064 , University of Illinois: UL1TR000050 , University of Pittsburgh: UL1TR000005 , UT Southwestern: 9U54TR000017-06 , University of Utah: UL1TR000105-05 , Vanderbilt University: UL1TR000445 , George Washington University: UL1TR000075 , University of CA, Davis: UL1TR000002 , University of Florida: UL1TR000064 , University of Michigan: UL1TR000433 .

Publisher Copyright:
© 2015 American Society of Hypertension.

Keywords

  • Cardiovascular disease
  • SPRINT
  • blacks
  • clinical trials
  • hypertension

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