Basal ganglia engagement during REM sleep movements in Parkinson’s disease

Ajay K. Verma, Sergio Francisco Acosta Lenis, Joshua E. Aman, David Escobar Sanabria, Jing Wang, Amy Pearson, Meghan E Hill, Remi Patriat, Lauren E Schrock, Scott Cooper, Michael Park, Noam Harel, Michael J Howell, Colum D. MacKinnon, Jerrold L. Vitek, Luke A Johnson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

To elucidate the role of the basal ganglia during REM sleep movements in Parkinson’s disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13–35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150–350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.

Original languageEnglish (US)
Article number116
Journalnpj Parkinson's Disease
Volume8
Issue number1
DOIs
StatePublished - Dec 2022

Bibliographical note

Funding Information:
We thank the participants in this study for their time and willingness to contribute to this research. We thank the entire University of Minnesota Udall team for their support of this study. We would like to acknowledge: Eric Maurer for leadership in Udall project management; Kelly Brown and Kelly Ryberg for patient recruitment and project management; Greg Molnar for his role in supporting initial investigations of sleep using DBS lead recordings; Ethan Marshall, Sinta Fergus, Stephanie Alberico, and Kevin O’Neill for help during data collections. This work was supported by the Udall Center for Excellence in Parkinson’s Disease, National Institutes of Health, National Institute of Neurological Disorders and Stroke: P50-NS123109, P50-NS098573, R01-NS110613, R01-NS058945, R01-NS037019, P30-NS076408, P41-EB027061; University of Minnesota’s NIH Clinical and Translational Science Award: UL1TR002494; MnDRIVE (Minnesota’s Discovery, Research and Innovation Economy) Brain Conditions Program; Engdahl Family Foundation; The Kurt B. Seydow Dystonia Foundation.

Funding Information:
J.E.A., N.H., R.P., M.C.P., and J.L.V. declares no competing non-financial interest but the following competing financial interests. J.E.A. – Consultant for Surgical Information Sciences Inc. N.H. - Consultant and a shareholder for Surgical Information Sciences Inc. R.P. - Consultant for Surgical Information Sciences Inc. M.C.P. - Listed faculty for University of Minnesota Educational Partnership with Medtronic, Inc., Minneapolis, MN, Consultant for: Zimmer Biomet, Synerfues, Inc, NeuroOne, Boston Scientific. Grant/Research support from: Medtronic, Inc., Boston Scientific, Abbott, SynerFuse, Inc., and Fasikl, Inc. J.L.V. - Dr. Vitek serves as a consultant for Medtronic, Boston Scientific and Abbott. He also serves on the Executive Advisory Board for Abbott and is a member of the scientific advisory board for Surgical Information Sciences. He has research support through the National Institutes of Health. All other authors have no competing interest to disclose.

Publisher Copyright:
© 2022, The Author(s).

PubMed: MeSH publication types

  • Journal Article

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