Banking and transplantation of unrelated donor umbilical cord blood: Status of the national heart, lung, and blood institute-sponsored trial

John E Wagner, J. Kurtzberg

Research output: Contribution to journalEditorial

17 Scopus citations

Abstract

Quarterly reports suggest that cryopreserved UCB from unrelated donors is a sufficient source of transplantable hematopoietic progenitor sales at least for small recipients. In addition to the rapid availability of and low rate of herpes-virus contamination of unrelated-donor UCB, the data further suggest that the probabilities of grade III to IV acute GVHD and extensive chronic GVHD may be lower than those observed after unrelated-donor marrow transplantation. The relative importance of graft cell dose and the acceptable degrees of HLA disparity in determining the outcome after unrelated-donor UCB transplantation must be determined. These outcomes will have major implications for banking practices and graft selection protocols specifically and for the future of UCB transplantation in general.

Original languageEnglish (US)
Pages (from-to)807-809
Number of pages3
JournalTransfusion
Volume38
Issue number9
DOIs
StatePublished - Jan 1 1998

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