Bacteriostatic activity and decomposition products of rifampicin in aqueous solution and liposomal composition

G. M. Sorokoumova; V. V. Vostrikov; A. A. Selishcheva; E. A. Rogozhkina; T. Yu Kalashnikova; V. I. Shvets; V. I. Golyshevskaya; L. P. Martynova; V. V. Erokhin

doi:10.1007/s11094-008-0153-3

Bacteriostatic activity and decomposition products of rifampicin in aqueous solution and liposomal composition

G. M. Sorokoumova
, V. V. Vostrikov
, A. A. Selishcheva
, E. A. Rogozhkina
, T. Yu Kalashnikova
, V. I. Shvets
, V. I. Golyshevskaya
, L. P. Martynova
, V. V. Erokhin

Biochemistry, Molecular Biology, and Biophysics (TMED)

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Products of the decomposition and oxidation of rifampicin were obtained; characterized by spectrophotometry, TLC, and HPLC; and identified by mass spectrometry. The stability of the drug in aqueous solutions and in liposomal compositions at 4 and 25°C was evaluated. The main product of rifampicin decomposition on storage is 3-formylrifampicin SV. The antimicrobial activity of the antibiotic in liposomal compositions is the same as that in aqueous solutions and is well retained on storage.

Original language	English (US)
Pages (from-to)	475-478
Number of pages	4
Journal	Pharmaceutical Chemistry Journal
Volume	42
Issue number	8
DOIs	https://doi.org/10.1007/s11094-008-0153-3
State	Published - Aug 2008

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10.1007/s11094-008-0153-3

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Sorokoumova, G. M., Vostrikov, V. V., Selishcheva, A. A., Rogozhkina, E. A., Kalashnikova, T. Y., Shvets, V. I., Golyshevskaya, V. I., Martynova, L. P., & Erokhin, V. V. (2008). Bacteriostatic activity and decomposition products of rifampicin in aqueous solution and liposomal composition. Pharmaceutical Chemistry Journal, 42(8), 475-478. https://doi.org/10.1007/s11094-008-0153-3

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title = "Bacteriostatic activity and decomposition products of rifampicin in aqueous solution and liposomal composition",

abstract = "Products of the decomposition and oxidation of rifampicin were obtained; characterized by spectrophotometry, TLC, and HPLC; and identified by mass spectrometry. The stability of the drug in aqueous solutions and in liposomal compositions at 4 and 25°C was evaluated. The main product of rifampicin decomposition on storage is 3-formylrifampicin SV. The antimicrobial activity of the antibiotic in liposomal compositions is the same as that in aqueous solutions and is well retained on storage.",

author = "Sorokoumova, \{G. M.\} and Vostrikov, \{V. V.\} and Selishcheva, \{A. A.\} and Rogozhkina, \{E. A.\} and Kalashnikova, \{T. Yu\} and Shvets, \{V. I.\} and Golyshevskaya, \{V. I.\} and Martynova, \{L. P.\} and Erokhin, \{V. V.\}",

year = "2008",

month = aug,

doi = "10.1007/s11094-008-0153-3",

language = "English (US)",

volume = "42",

pages = "475--478",

journal = "Pharmaceutical Chemistry Journal",

issn = "0091-150X",

publisher = "Springer New York",

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TY - JOUR

T1 - Bacteriostatic activity and decomposition products of rifampicin in aqueous solution and liposomal composition

AU - Sorokoumova, G. M.

AU - Vostrikov, V. V.

AU - Selishcheva, A. A.

AU - Rogozhkina, E. A.

AU - Kalashnikova, T. Yu

AU - Shvets, V. I.

AU - Golyshevskaya, V. I.

AU - Martynova, L. P.

AU - Erokhin, V. V.

PY - 2008/8

Y1 - 2008/8

N2 - Products of the decomposition and oxidation of rifampicin were obtained; characterized by spectrophotometry, TLC, and HPLC; and identified by mass spectrometry. The stability of the drug in aqueous solutions and in liposomal compositions at 4 and 25°C was evaluated. The main product of rifampicin decomposition on storage is 3-formylrifampicin SV. The antimicrobial activity of the antibiotic in liposomal compositions is the same as that in aqueous solutions and is well retained on storage.

AB - Products of the decomposition and oxidation of rifampicin were obtained; characterized by spectrophotometry, TLC, and HPLC; and identified by mass spectrometry. The stability of the drug in aqueous solutions and in liposomal compositions at 4 and 25°C was evaluated. The main product of rifampicin decomposition on storage is 3-formylrifampicin SV. The antimicrobial activity of the antibiotic in liposomal compositions is the same as that in aqueous solutions and is well retained on storage.

UR - https://www.scopus.com/pages/publications/57849159059

UR - https://www.scopus.com/pages/publications/57849159059#tab=citedBy

U2 - 10.1007/s11094-008-0153-3

DO - 10.1007/s11094-008-0153-3

M3 - Article

AN - SCOPUS:57849159059

SN - 0091-150X

VL - 42

SP - 475

EP - 478

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

IS - 8

ER -

Bacteriostatic activity and decomposition products of rifampicin in aqueous solution and liposomal composition

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