Bacteriostatic activity and decomposition products of rifampicin in aqueous solution and liposomal composition

G. M. Sorokoumova, V. V. Vostrikov, A. A. Selishcheva, E. A. Rogozhkina, T. Yu Kalashnikova, V. I. Shvets, V. I. Golyshevskaya, L. P. Martynova, V. V. Erokhin

Research output: Contribution to journalArticle

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Abstract

Products of the decomposition and oxidation of rifampicin were obtained; characterized by spectrophotometry, TLC, and HPLC; and identified by mass spectrometry. The stability of the drug in aqueous solutions and in liposomal compositions at 4 and 25°C was evaluated. The main product of rifampicin decomposition on storage is 3-formylrifampicin SV. The antimicrobial activity of the antibiotic in liposomal compositions is the same as that in aqueous solutions and is well retained on storage.

Original languageEnglish (US)
Pages (from-to)475-478
Number of pages4
JournalPharmaceutical Chemistry Journal
Volume42
Issue number8
DOIs
StatePublished - Aug 1 2008

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