Bacterial persistence in vivo: resistance or tolerance to antibiotics.

J. F. Acar, L. D. Sabath

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The in vivo persistence of bacteria in spite of "adequate" therapy may be due to a variety of causes or factors. The most "obvious" cause is the presence of drug resistant strains, missed in conventional testing because of heterogeneity of resistance, special test requirements or emergence during treatment. A second large group of causes is due to atypical forms, whereas a third cause is due to tolerance. A fourth group of causes may be termed invironmental factors, and this includes drug inactivation, bioconversion or antagonism, often a result of the infection itself. [References: 55]
Original languageEnglish (US)
Pages (from-to)86-91
Number of pages6
JournalScandinavian Journal of Infectious Diseases Supplement
Volume14
Issue number14
StatePublished - 1978

Keywords

  • Animals
  • Anti-Bacterial Agents/me [Metabolism]
  • Anti-Bacterial Agents/tu [Therapeutic Use]
  • Bacteria/en [Enzymology]
  • Bacterial Infections/dt [Drug Therapy]
  • Biotransformation
  • Drug Resistance, Microbial
  • Humans
  • L Forms

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