Abstract
Paediatric leukaemia has a long tail of driver mutations each of which must be ‘backtracked’ to samples taken at birth to identify the prenatal origin of a subtype. Presently, Bardini et al. describe the first successful backtracking of an NUTM1 rearrangement, which sheds light on the biology of this particular alteration. Continued backtracking of NUTM1 rearrangements, and all leukaemia-typical somatic alterations, is necessary to fully understand the prenatal origin of these diseases. Commentary on: Bardini et al. Prenatal origin of NUTM1 gene rearrangement in infant B-cell precursor acute lymphoblastic leukaemia. Br J Haematol 2024; 205:1883-1888.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1670-1671 |
| Number of pages | 2 |
| Journal | British journal of haematology |
| Volume | 205 |
| Issue number | 5 |
| DOIs |
|
| State | Published - Nov 2024 |
Bibliographical note
Publisher Copyright:© 2024 British Society for Haematology and John Wiley & Sons Ltd.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- acute lymphoblastic leukemia
- infant B-cell precursor
- leukemia-forming NUTM1 rearrangement
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