B lymphocyte regulation of human hematopoiesis

F. M. Uckun, D. A. Vallera, S. L. Wee

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Epstein Barr virus (EBV)-transformed B lymphoblastoid cell lines (BLCL) were derived from seven different individuals. The ability of BLCL supernatants to stimulate hematopoietic colony formation in vitro was tested in a conventional stem cell assay system. Supernatants promoted the growth of single (GM, E, MK) as well as multi-lineage (GEMM) colonies in bone marrow cultures. Our results indicate that EBV-transformed B lymphocytes produce cytokines that affect in vitro stem cell proliferation and differentiation. These studies demonstrate the regulatory potential of activated B lymphocytes in human hematopoiesis.

Original languageEnglish (US)
Pages (from-to)3817-3822
Number of pages6
JournalJournal of Immunology
Issue number6
StatePublished - 1985


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